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Findings on Tissue Engineering from R.J. Nesbitt and Colleagues Provide New Insights (Primary and secondary restraints of human and ovine knees for...

August 13, 2014



Findings on Tissue Engineering from R.J. Nesbitt and Colleagues Provide New Insights (Primary and secondary restraints of human and ovine knees for simulated in vivo gait kinematics)

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Tissue Engineering. According to news reporting out of Cincinnati, Ohio, by NewsRx editors, research stated, "Knee soft tissue structures are frequently injured, leading to the development of osteoarthritis even with treatment. Understanding how these structures contribute to knee function during activities of daily living (ADLs) is crucial in creating more effective treatments."

Our news journalists obtained a quote from the research, "This study was designed to determine the role of different knee structures during a simulated ADL in both human knees and ovine stifle joints. A six degree-of-freedom robot was used to reproduce each species' in vivo gait while measuring three-dimensional joint forces and torques. Using a semi-randomized selective cutting method, we determined the primary and secondary structures contributing to the forces and torques along and about each anatomical axis. In both species, the bony interaction, ACL, and medial meniscus provided most of the force contributions during stance, whereas the ovine MCL, human bone, and ACLs of both species were the key contributors during swing. This study contributes to our overarching goal of establishing functional tissue engineering parameters for knee structures by further validating biomechanical similarities between the ovine model and the human to provide a platform for measuring biomechanics during an in vivo ADL."

According to the news editors, the research concluded: "These parameters will be used to develop more effective treatments for knee injuries to reduce or eliminate the incidence of osteoarthritis."

For more information on this research see: Primary and secondary restraints of human and ovine knees for simulated in vivo gait kinematics. Journal of Biomechanics, 2014;47(9):2022-2027. Journal of Biomechanics can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Journal of Biomechanics - www.elsevier.com/wps/product/cws_home/321)

Our news journalists report that additional information may be obtained by contacting R.J. Nesbitt, Cincinnati Sports Med, Cincinnati, OH, United States. Additional authors for this research include S.T. Herfat, D.V. Boguszewski, A.J. Engel, M.T. Galloway and J.T. Shearn (see also Tissue Engineering).

Keywords for this news article include: Ohio, Tissue Engineering, Cincinnati, United States, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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