Findings on Oligopeptides Reported by Investigators at Nanjing University [Delivery of platinum(IV) drug to subcutaneous tumor and lung metastasis using bradykinin-potentiating peptide-decorated chitosan nanoparticles]
By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Peptides. According to news originating from Jiangsu, People's Republic of China, by NewsRx correspondents, research stated, "Selectively activating tumor vessels to increase drug delivery and reduce interstitial fluid pressure of tumors is actively pursued. Here we developed a vasoactive peptide-decorated chitosan nanoparticles for enhancing drug accumulation and penetration in subcutaneous tumor and lung metastasis."
Our news journalists obtained a quote from the research from Nanjing University, "The vasoactive peptide used here is bradykinin-potentiating peptide (BPP) containing 9 amino acid residues and the drug is bioreductively sensitive platinum(IV) compound which becomes cisplatin in intracellular reductive environments. Both peptide and drug are covalently linked with chitosan nanoparticles with a diameter of 120 nm. We demonstrate that BPP-decorated chitosan nanoparticles increase the tumorous vascular permeability and reduce the interstitial fluid pressure of tumor simultaneously, both of which improve the penetration of nanoparticles in tumor tissues. The in vivo biodistribution and tumor inhibition examinations demonstrate that the BPP-decorated nanoparticle formulation has more superior efficacy in enhancing drug accumulation in tumor, restraining tumor growth and prolonging the lifetime of tumor-bearing mice than free drug and non-decorated nanoparticle formulation. Meanwhile, the drug accumulation in the lung with metastasis reaches 17% and 20% injected dose per gram of lung for the chitosan nanoparticles without and with BPP decoration, respectively, which is 10-fold larger than that of free cisplatin."
According to the news editors, the research concluded: "The examination of lung metastasis inhibition further indicates that BPP-decorated chitosan nanoparticle formulations can more effectively inhibit lung metastasis."
For more information on this research see: Delivery of platinum(IV) drug to subcutaneous tumor and lung metastasis using bradykinin-potentiating peptide-decorated chitosan nanoparticles. Biomaterials, 2014;35(24):6439-6453. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
The news correspondents report that additional information may be obtained from X. Wang, Nanjing University, Dept. of Polymer Sci & Engn, Coll Chem & Chem Engn, Jiangsu Key Lab Nanotechnol, Nanjing 210008, Jiangsu, People's Republic of China. Additional authors for this research include C.C. Yang, Y.J. Zhang, X. Zhen, W. Wu and X.Q. Jiang (see also Peptides).
Keywords for this news article include: Asia, Jiangsu, Bradykinin, Nanoparticle, Neuropeptides, Oligopeptides, Nanotechnology, Emerging Technologies, People's Republic of China
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