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Findings from Yale University in the Area of Drug Delivery Systems Described (The effect of hyperbranched polyglycerol coatings on drug delivery...

August 13, 2014



Findings from Yale University in the Area of Drug Delivery Systems Described (The effect of hyperbranched polyglycerol coatings on drug delivery using degradable polymer nanoparticles)

By a News Reporter-Staff News Editor at Biotech Week -- A new study on Drugs and Therapies is now available. According to news originating from New Haven, Connecticut, by NewsRx correspondents, research stated, "A key attribute for nanoparticles (NPs) that are used in medicine is the ability to avoid rapid uptake by phagocytic cells in the liver and other tissues. Poly(ethylene glycol) (PEG) coatings has been the gold standard in this regard for several decades."

Our news journalists obtained a quote from the research from Yale University, "Here, we examined hyperbranched polyglycerols (HPG) as an alternate coating on NPs. In earlier work, HPG was modified with amines and subsequently conjugated to poly(lactic acid) (PLA), but that approach compromised the ability of HPG to resist non-specific adsorption of biomolecules. Instead, we synthesized a copolymer of PLA HPG by a one-step esterification. NPs were produced from a single emulsion using PLA HPG: fluorescent dye or the anti-tumor agent camptothecin (CPT) were encapsulated at high efficiency in the NPs. PLA HPG NPs were quantitatively compared to PLA PEG NPs, produced using approaches that have been extensively optimized for drug delivery in humans. Despite being similar in size, drug release profile and in vitro cytotoxicity, the PLA-HPG NPs showed significantly longer blood circulation and significantly less liver accumulation than PLA PEG. CPT-loaded PLA HPG NPs showed higher stability in suspension and better therapeutic effectiveness against tumors in vivo than CPT-loaded PLA PEG NPs."

According to the news editors, the research concluded: "Our results suggest that HPG is superior to PEG as a surface coating for NPs in drug delivery."

For more information on this research see: The effect of hyperbranched polyglycerol coatings on drug delivery using degradable polymer nanoparticles. Biomaterials, 2014;35(24):6595-6602. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)

The news correspondents report that additional information may be obtained from Y. Deng, Yale University, Dept. of Chem & Environm Engn, New Haven, CT 06511, United States. Additional authors for this research include J.K. Saucier-Sawyer, C.J. Hoimes, J.W. Zhang, Y.E. Seo, J.W. Andrejecsk and W.M. Saltzman (see also Drugs and Therapies).

Keywords for this news article include: New Haven, Connecticut, Nanoparticle, United States, Nanotechnology, Drugs and Therapies, Drug Delivery Systems, Emerging Technologies, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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