Findings from University of Kebangsaan Reveals New Findings on Nanoparticles (Antibacterial effects of chitosan-tripolyphosphate nanoparticles: impact of particle size molecular weight)
By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Nanoparticles have been published. According to news reporting originating in Kuala Lumpur, Malaysia, by NewsRx journalists, research stated, "This study revealed not only the antibacterial potential of smaller chitosan-tripolyphosphate nanoparticles (CS-TPP NPs) over larger ones, but also the attempt has been made to demonstrate antibacterial mechanism of action of CS-TPP NPs on the bacterial cell membrane. Several aspects of low-molecular-weight (LMW) and high-molecular-weight (HMW) CS-TPP NPs were evaluated by their interactions with selected Gram-positive and Gram-negative bacteria."
The news reporters obtained a quote from the research from the University of Kebangsaan, "The interaction of CS-TPP NPs with synthetic phospholipid membranes was also evaluated using Fourier transform infrared spectroscopy. The permeabilities of the bacterial outer and inner membranes were evaluated by determining the uptake of a fluorescent probe, 1-N-phenylnaphthylamine, and the release of cytoplasmic beta-galactosidase. The morphology of the bacteria treated with LMW and HMW CS-TPP NPs was investigated using transmission electron microscopy. Flow cytometric analysis was also performed for the quantification of dead and surviving bacteria. These studies indicated that the antibacterial effects of LMW CS-TPP NPs (196 and 394 nm) were superior to those HMW CS-TPP NPs (598 and 872 nm)."
According to the news reporters, the research concluded: "These data indicated that the antibacterial activity of CS-TPP NPs was negatively correlated with particle size and molecular weight, and that CS-TPP NPs represent a promising antimicrobial adjunct."
For more information on this research see: Antibacterial effects of chitosan-tripolyphosphate nanoparticles: impact of particle size molecular weight. Journal of Nanoparticle Research, 2014;16(7):1-14. Journal of Nanoparticle Research can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; Journal of Nanoparticle Research - www.springerlink.com/content/1388-0764/)
Our news correspondents report that additional information may be obtained by contacting A. Sarwar, Univ Kebangsaan Malaysia, Fac Hlth Sci, Novel Antibiot Res Grp, Kuala Lumpur 50300, Malaysia. Additional authors for this research include H. Katas and N.M. Zin (see also Nanoparticles).
Keywords for this news article include: Asia, Malaysia, Kuala Lumpur, Nanotechnology, Emerging Technologies
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