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Findings from University of Colorado Has Provided New Data on Mononuclear Phagocyte System (Comparative Genomics RNAi Screen Identifies Eftud2 as a...

August 15, 2014



Findings from University of Colorado Has Provided New Data on Mononuclear Phagocyte System (Comparative Genomics RNAi Screen Identifies Eftud2 as a Novel Regulator of Innate Immunity)

By a News Reporter-Staff News Editor at Health & Medicine Week -- Research findings on Immunology are discussed in a new report. According to news reporting originating from Aurora, Colorado, by NewsRx correspondents, research stated, "The extent of the innate immune response is regulated by many positively and negatively acting signaling proteins. This allows for proper activation of innate immunity to fight infection while ensuring that the response is limited to prevent unwanted complications."

Our news editors obtained a quote from the research from the University of Colorado, "Thus mutations in innate immune regulators can lead to immune dysfunction or to inflammatory diseases such as arthritis or atherosclerosis. To identify novel innate immune regulators that could affect infectious or inflammatory disease, we have taken a comparative genomics RNAi screening approach in which we inhibit orthologous genes in the nematode Caenorhabditis elegans and murine macrophages, expecting that genes with evolutionarily conserved function also will regulate innate immunity in humans. Here we report the results of an RNAi screen of approximately half of the C. elegans genome, which led to the identification of many candidate genes that regulate innate immunity in C. elegans and mouse macrophages."

According to the news editors, the research concluded: "One of these novel conserved regulators of innate immunity is the mRNA splicing regulator Eftud2, which we show controls the alternate splicing of the MyD88 innate immunity signaling adaptor to modulate the extent of the innate immune response."

For more information on this research see: Comparative Genomics RNAi Screen Identifies Eftud2 as a Novel Regulator of Innate Immunity. Genetics, 2014;197(2):485-84. Genetics can be contacted at: Genetics Society America, 9650 Rockville Ave, Bethesda, MD 20814, USA. (Cell Press - www.cell.com; Genetics - www.cell.com/trends/genetics/home)

The news editors report that additional information may be obtained by contacting L. De Arras, University of Colorado, Dept. of Med, Aurora, CO 80045, United States. Additional authors for this research include R. Laws, S.M. Leach, K. Pontis, J.H. Freedman, D.A. Schwartz and S. Alper (see also Immunology).

Keywords for this news article include: Aurora, Colorado, Immunology, Macrophages, United States, North and Central America, Mononuclear Phagocyte System

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Health & Medicine Week


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