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Findings from Seoul National University in Protein Nanoparticles Reported (Engineered protein nanoparticles for in vivo tumor detection)

August 12, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- New research on Protein Nanoparticles is the subject of a report. According to news originating from Seoul, South Korea, by NewsRx correspondents, research stated, "Two different protein nanoparticles that are totally different in shape and surface structure, i.e. Escherichia coli DNA-binding protein (eDPS) (spherical, 10 nm) and Thermoplasma acidophilum proteasome (tPTS) (cylindrical, 12 x 15 nm) were engineered for in vivo optical tumor detection: arginine-glycine-aspartic acid (RGD) peptide (CDCRGDCFC) was genetically inserted to the surface of each protein nanoparticle, and also near-infrared fluorescence dye was chemically linked to the surface lysine residues."

Our news journalists obtained a quote from the research from Seoul National University, "The specific affinity of RGD for integrin (alpha(v)beta(3)) facilitated the uptake of RGD-presenting protein nanoparticles by integrin-expressing tumor cells, and also the protein nanoparticles neither adversely affected cell viability nor induced cell damage. After intravenously injected to tumor-bearing mice, all the protein nanoparticles successfully reached tumor with negligible renal clearance, and then the surface RGD peptides caused more prolonged retention of protein nanoparticles in tumor and accordingly higher fluorescence intensity of tumor image. In particular, the fluorescence of tumor image was more intensive with tPTS than eDPS, which is due presumably to longer in vivo half-life and circulation of tPTS that originates from thermophilic and acidophilic bacterium."

According to the news editors, the research concluded: "Although eDPS and tPTS were used as proof-of-concept in this study, it seems that other protein nanoparticles with different size, shape, and surface structure can be applied to effective in vivo tumor detection."

For more information on this research see: Engineered protein nanoparticles for in vivo tumor detection. Biomaterials, 2014;35(24):6422-6429. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier -; Biomaterials -

The news correspondents report that additional information may be obtained from K.Y. Ahn, Seoul National University, Grad Sch Convergence Sci & Technol, Dept. of Mol Med & Biopharmaceut Sci, Seoul 151742, South Korea. Additional authors for this research include H.K. Ko, B.R. Lee, E.J. Lee, J.H. Lee, Y. Byun, I.C. Kwon, K. Kim and J. Lee (see also Protein Nanoparticles).

Keywords for this news article include: Asia, Seoul, South Korea, Engineering, Nanotechnology, Emerging Technologies, Protein Nanoparticles

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Source: Life Science Weekly

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