Findings from National Institute of Genetic Engineering and Biotechnology Reveals New Findings on Ibuprofen Therapy (Synthesis and evaluation of PEG-O-chitosan nanoparticles for delivery of poor water soluble drugs: Ibuprofen)
By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Drugs and Therapies. According to news reporting out of Tehran, Iran, by NewsRx editors, research stated, "Current methods for preparation of PEGylated chitosan have limitations such as harsh de protecting step and several purification cycles. In the present study, a facile new method for conjugating methoxy polyethylene glycol (mPEG) to chitosan under mild condition is introduced to improve water solubility of chitosan and control the release of poor water soluble drugs."
Our news journalists obtained a quote from the research from the National Institute of Genetic Engineering and Biotechnology, "The method consists of chitosan modification by grafting the C6 position of chitosan to mPEG which is confirmed by Fourier transformed-infrared (FT-IR) and proton nuclear magnetic resonance ((HNMR)-H-1) analyses. The amine groups at the C2 position of chitosan are protected using sodium dodecylsulfate (SDS) which is removed by dialyzing the precipitation against Tris solution. The chemical structure of the prepared polymer is characterized by FTIR and (HNMR)-H-1. The synthesized polymer is then employed to prepare nanoparticles which are characterized by transmission electron microscopy (TEM), atomic force microscopy (AFM), scanning electron microscopy (SEM), and dynamic light scattering (DLS) for their size and morphology. The nanoparticles are used for encapsulation of ibuprofen followed by in vitro release investigation in gastrointestinal and simulated biological fluids. The chitosan nanoparticles are used as control. The PEGylated nanoparticles show a particle size of 80 nm with spherical morphology. The results clearly show that drug release from PEGylated chitosan nanoparticles is remarkably slower than chitosan. In addition, drug encapsulation and encapsulation efficiency in PEGylated nanopartides are dependent on the amount of drug added to the formulation being significantly higher than chitosan nanoparticles."
According to the news editors, the research concluded: "This study provides an efficient, novel, and facile method for preparing a nano carrier system for delivery of water insoluble drugs."
For more information on this research see: Synthesis and evaluation of PEG-O-chitosan nanoparticles for delivery of poor water soluble drugs: Ibuprofen. Materials Science & Engineering C-Materials for Biological Applications, 2014;41():91-99. Materials Science & Engineering C-Materials for Biological Applications can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands (see also Drugs and Therapies).
Our news journalists report that additional information may be obtained by contacting A.H. Najafabadi, Natl Inst Genet Engn & Biotechnol, Tissue Engn & Biomat Div, Tehran 14965161, Iran. Additional authors for this research include M. Abdouss and S. Faghihi.
Keywords for this news article include: Iran, Asia, Pharmaceuticals, Tehran, Ibuprofen, Nanoparticle, Nanotechnology, Phenylpropionates, Drugs and Therapies, Emerging Technologies
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