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Findings from Chongqing University Has Provided New Data on Nanoparticles (Redox-Responsive Nanocarrier Based on Heparin End-Capped Mesoporous Silica...

August 13, 2014



Findings from Chongqing University Has Provided New Data on Nanoparticles (Redox-Responsive Nanocarrier Based on Heparin End-Capped Mesoporous Silica Nanoparticles for Targeted Tumor Therapy in Vitro and in Vivo)

By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Nanoparticles have been published. According to news reporting out of Chongqing, People's Republic of China, by NewsRx editors, research stated, "This study reports a smart controlled drug release system based on mesoporous silica nanoparticles (MSNs) for targeted drug delivery. The system was fabricated by employing heparin as an end-capping agent to seal the mesopores of MSNs via disulfide bonds as intermediate linkers for intracellular glutathione triggered drug release."

Our news journalists obtained a quote from the research from Chongqing University, "Lactobionic acid molecules were then coupled to heparin end-capped MSNs that serve as targeting motifs for facilitating the uptake of doxorubicin (DOX) loaded MSNs by HepG2 cells and tumors, respectively. Detailed investigations demonstrated that the fabricated drug delivery systems could deliver DOX to cancer cells to induce cell apoptosis in vitro and tumor tissue for the inhibition of tumor growth in vivo with minimal side effects."

According to the news editors, the research concluded: "The study affords a promising nanocarrier for redox-responsive cargo delivery with high curative efficiency for cancer therapy."

For more information on this research see: Redox-Responsive Nanocarrier Based on Heparin End-Capped Mesoporous Silica Nanoparticles for Targeted Tumor Therapy in Vitro and in Vivo. Langmuir, 2014;30(26):7867-7877. Langmuir can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Langmuir - www.pubs.acs.org/journal/langd5)

Our news journalists report that additional information may be obtained by contacting L.L. Dai, Chongqing Univ, Coll Bioengn, Minist Educ, Key Lab Biorheol Sci & Technol, Chongqing 400044, People's Republic of China. Additional authors for this research include J.H. Li, B.L. Zhang, J.J. Liu, Z. Luo and K.Y. Cai (see also Nanoparticles).

Keywords for this news article include: Asia, Therapy, Chongqing, Nanotechnology, Emerging Technologies, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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