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Findings from Chinese Academy of Science Has Provided New Data on Numerical Modeling (Numerical simulations on conformable laser-induced interstitial...

August 15, 2014



Findings from Chinese Academy of Science Has Provided New Data on Numerical Modeling (Numerical simulations on conformable laser-induced interstitial thermotherapy through combined use of multi-beam heating and biodegradable nanoparticles)

By a News Reporter-Staff News Editor at Health & Medicine Week -- Researchers detail new data in Numerical Modeling. According to news reporting originating from Beijing, People's Republic of China, by NewsRx correspondents, research stated, "Clinically, precisely heating and thus completely ablating diseased tumor tissue through laser beam is still facing many technical challenges. In this study, numerical simulation of a conformal heating modality based on multi-beam laser along with biodegradable magnesium nanoparticles (Mg-NPs) was put forward to treat liver tumor with large size or irregular shape."

Our news editors obtained a quote from the research from the Chinese Academy of Science, "Further, a Gaussian-like distribution was proposed to investigate the influence of Mg-NP deposition on the nanoenhanced laser-induced interstitial thermotherapy (LITT). A temperature feedback system was adopted to control the temperature range to avoid overheating. To preliminarily validate the heating enhancement induced by the applied multi-beam laser and Mg-NPs, a conceptual experiment was performed. Both theoretical simulation and experimental measurements demonstrated that multi-beam laser with Mg-NPs could improve efficiency in the conformal heating of tumors with irregular shape or large size. In addition, the distribution and content of Mg-NPs produced significant impact on thermotherapy: (1) The adjustable parameter sigma in the Gaussian-like distribution could reflect various practical situations and diffusivities of Mg-NPs; (2) under the premise of the same concentration of Mg-NPs and short time to heat a small-sized target, the whole liver tumor containing Mg-NPs could not improve the efficiency as the nanoparticles limited the photons to be absorbed only around the fibers, while liver tumor partially containing Mg-NPs could improve the thermotherapy efficiency up to 20 %; and (3) the addition of Mg-NPs was rather beneficial for realizing a conformal heating as the residual thermal energy was much less than that without Mg-NPs."

According to the news editors, the research concluded: "This study suggests a feasible and promising modality for planning a high-performance LITT in future clinics."

For more information on this research see: Numerical simulations on conformable laser-induced interstitial thermotherapy through combined use of multi-beam heating and biodegradable nanoparticles. Lasers in Medical Science, 2014;29(4):1505-1516. Lasers in Medical Science can be contacted at: Springer London Ltd, 236 Grays Inn Rd, 6TH Floor, London WC1X 8HL, England. (Springer - www.springer.com; Lasers in Medical Science - www.springerlink.com/content/0268-8921/)

The news editors report that additional information may be obtained by contacting J. Zhang, Chinese Academy Sci, Technical Inst Phys & Chem, Key Lab Cryogen, Beijing 100190, People's Republic of China. Additional authors for this research include C. Jin, Z.Z. He and J. Liu (see also Numerical Modeling).

Keywords for this news article include: Asia, Beijing, Mathematics, Nanoparticle, Nanotechnology, Numerical Modeling, Emerging Technologies, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Health & Medicine Week


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