Data on Tissue Engineering Detailed by Researchers at University of Michigan Health System (Acoustic droplet-hydrogel composites for spatial and temporal control of growth factor delivery and scaffold stiffness)
By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Biomedicine and Biomedical Engineering have been published. According to news reporting out of Ann Arbor, Michigan, by NewsRx editors, research stated, "Wound healing is regulated by temporally and spatially restricted patterns of growth factor signaling, but there are few delivery vehicles capable of the 'on-demand' release necessary for recapitulating these patterns. Recently we described a perfluorocarbon double emulsion that selectively releases a protein payload upon exposure to ultrasound through a process known as acoustic droplet vaporization (ADV)."
Our news journalists obtained a quote from the research from the University of Michigan Health System, "In this study, we describe a delivery system composed of fibrin hydrogels doped with growth factor-loaded double emulsion for applications in tissue regeneration. Release of immunoreactive basic fibroblast growth factor (bFGF) from the composites increased up to 5-fold following ADV and delayed release was achieved by delaying exposure to ultrasound. Releasates of ultrasound-treated materials significantly increased the proliferation of endothelial cells compared to sham controls, indicating that the released bFGF was bioactive. ADV also triggered changes in the ultrastructure and mechanical properties of the fibrin as bubble formation and consolidation of the fibrin in ultrasound-treated composites were accompanied by up to a 22-fold increase in shear stiffness. ADV did not reduce the viability of cells suspended in composite scaffolds."
According to the news editors, the research concluded: "These results demonstrate that an acoustic droplet-hydrogel composite could have broad utility in promoting wound healing through on-demand control of growth factor release and/or scaffold architecture."
For more information on this research see: Acoustic droplet-hydrogel composites for spatial and temporal control of growth factor delivery and scaffold stiffness. Acta Biomaterialia, 2013;9(7):7399-409. (Elsevier - www.elsevier.com; Acta Biomaterialia - www.elsevier.com/wps/product/cws_home/702994)
Our news journalists report that additional information may be obtained by contacting M.L. Fabiilli, Dept. of Radiology, University of Michigan Health System, Ann Arbor, MI, United States. Additional authors for this research include C.G. Wilson, F. Padilla, F.M. Martin-Saavedra, J.B. Fowlkes and R.T Franceschi (see also Biomedicine and Biomedical Engineering).
Keywords for this news article include: Tissue Engineering, Biomedicine and Biomedical Engineering, Michigan, Alcohols, Hydrogel, Ann Arbor, United States, Bioengineering, Organic Chemicals, Polyethylene Glycols, North and Central America.
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