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Data on Neurons Detailed by Researchers at School of Life Science (An in vitro toxicity evaluation of gold-, PLLA- and PCL-coated silica...

August 15, 2014



Data on Neurons Detailed by Researchers at School of Life Science (An in vitro toxicity evaluation of gold-, PLLA- and PCL-coated silica nanoparticles in neuronal cells for nanoparticle-assisted laser-tissue soldering)

By a News Reporter-Staff News Editor at Health & Medicine Week -- Fresh data on Neurons are presented in a new report. According to news originating from Muttenz, Switzerland, by NewsRx correspondents, research stated, "The uptake of silica (Si) and gold (Au) nanoparticles (NPs) engineered for laser-tissue soldering in the brain was investigated using microglial cells and undifferentiated and differentiated SH-SY5Y cells. It is not known what effects NPs elicit once entering the brain."

Our news journalists obtained a quote from the research from the School of Life Science, "Cellular uptake, cytotoxicity, apoptosis, and the potential induction of oxidative stress by means of depletion of glutathione levels were determined after NP exposure at concentrations of 10(3) and 10(9) NPs/ml. Au-, silica poly (epsilon-caprolactone) (Si-PCL-) and silica poly-t-lactide (Si-PLLA)-NPs were taken up by all cells investigated. Aggregates and single NPs were found in membrane-surrounded vacuoles and the cytoplasm, but not in the nucleus. Both NP concentrations investigated did not result in cytotoxicity or apoptosis, but reduced glutathione (GSH) levels predominantly at 6 and 24 h, but not after 12 h of NP exposure in the microglial cells. NP exposure-induced GSH depletion was concentration-dependent in both cell lines. Si-PCL-NPs induced the strongest effect of GSH depletion followed by Si-PLLA-NPs and Au-NPs. NP size seems to be an important characteristic for this effect. Overall, Au-NPs are most promising for laser-assisted vascular soldering in the brain."

According to the news editors, the research concluded: "Further studies are necessary to further evaluate possible effects of these NPs in neuronal cells."

For more information on this research see: An in vitro toxicity evaluation of gold-, PLLA- and PCL-coated silica nanoparticles in neuronal cells for nanoparticle-assisted laser-tissue soldering. Toxicology in Vitro, 2014;28(5):990-998. Toxicology in Vitro can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. (Elsevier - www.elsevier.com; Toxicology in Vitro - www.elsevier.com/wps/product/cws_home/800)

The news correspondents report that additional information may be obtained from F. Koch, Sch Life Sci, CH-4132 Muttenz, Switzerland. Additional authors for this research include A.M. Moller, M. Frenz, U. Pieles, K. Kuehni-Boghenbor and M. Mevissen (see also Neurons).

Keywords for this news article include: Cells, Europe, Muttenz, Neurons, Switzerland, Nanoparticle, Nanotechnology, Silicon Nanocrystals, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Health & Medicine Week


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