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Data on Nanoparticles Discussed by Researchers at University of Cincinnati (One-pot facile synthesis of PEGylated superparamagnetic iron oxide...

August 15, 2014



Data on Nanoparticles Discussed by Researchers at University of Cincinnati (One-pot facile synthesis of PEGylated superparamagnetic iron oxide nanoparticles for MRI contrast enhancement)

By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Nanoparticles have been published. According to news reporting out of Cincinnati, Ohio, by NewsRx editors, research stated, "Polyethylene glycol (PEG)-coated superparamagnetic iron oxide nanoparticles (PEG.SPIONs) were prepared by a facile one-pot approach. The synthesized PEG.SPIONs were found to be uniform in size with an average hydrodynamic diameter of 11.7 nm."

Our news journalists obtained a quote from the research from the University of Cincinnati, "PEG.SPIONs exhibited excellent dispersibility in water, colloidal stability, and biocompatibility. The magnetic resonance imaging (MRI) properties of PEG.SPIONs were characterized both in vitro and in vivo. The dual contrast both in T-1 and T-2-weighted imaging was well enhanced with longitudinal and transverse relaxivity (r(1), r(2)) of 35.92 s(-1) per mM of Fe3+ and 206.91 s(-1) per mM of Fe3+ respectively. In vivo T-2-weighted MRI shows pronounced enhancement in the liver and spleen but not in T-1-weighted MRI. Accumulations of nanoparticles were found primarily in the liver, spleen, and intestine, while much lower uptake in the kidney, heart, and lungs. A gradual excretion of PEG.SPIONs was observed via hepatobiliary (HB) processing over a period of 14 days. The toxicity of PEG.SPIONs was also evaluated in vitro and in vivo. PEG.SPIONs were found to be biocompatible by investigating organ tissues after hematoxylin-eosin staining."

According to the news editors, the research concluded: "The conclusion of the study indicates a high potential of PEG.SPIONs in medical MRI."

For more information on this research see: One-pot facile synthesis of PEGylated superparamagnetic iron oxide nanoparticles for MRI contrast enhancement. Materials Science & Engineering C-Materials for Biological Applications, 2014;41():161-167. Materials Science & Engineering C-Materials for Biological Applications can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands (see also Nanoparticles).

Our news journalists report that additional information may be obtained by contacting L.L. Dai, University of Cincinnati, Coll Engn & Appl Sci, Dept. of Mech & Mat Engn, Mat Sci & Engn Program, Cincinnati, OH 45221, United States. Additional authors for this research include Y.K. Liu, Z.Q. Wang, F.F. Guo, D.L. Shi and B.B. Zhang.

Keywords for this news article include: Ohio, Cincinnati, United States, Nanotechnology, Emerging Technologies, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Health & Medicine Week


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