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Data from Tokyo University of Science Provide New Insights into Keratinocytes (Involvement of P2Y11 receptor in silica nanoparticles 30-induced IL-6...

August 12, 2014



Data from Tokyo University of Science Provide New Insights into Keratinocytes (Involvement of P2Y11 receptor in silica nanoparticles 30-induced IL-6 production by human keratinocytes)

By a News Reporter-Staff News Editor at Life Science Weekly -- New research on Keratinocytes is the subject of a report. According to news reporting out of Chiba, Japan, by NewsRx editors, research stated, "We have previously reported that P2Y11 receptor mediates IFN-gamma-induced IL-6 production in human keratinocytes, suggesting the importance of purinergic signaling in skin inflammatory diseases. In this study, the involvement of various P2 receptors in IL-6 production induced by silica nanoparticle 30 (SNP30) was examined in a human keratinocyte cell line, HaCaT."

Our news journalists obtained a quote from the research from the Tokyo University of Science, "Exposure to SNP30 increased IL-6 production in the cells. Ecto-nucleotidase (apyrase), a non-selective antagonist of P2Y receptors (suramin), and a selective P2Y11 receptor antagonist (NF157) all inhibited IL-6 production. Nucleotides such as ATP and UTP themselves also significantly increased IL-6 production in the cells. It was further confirmed that ATP was released from HaCaT cells exposed to SNP30. These results support the possible role of ATP in SNP30-induced IL-6 production by HaCaT cells."

According to the news editors, the research concluded: "These data demonstrate that P2Y11 receptor also mediates SNP30-induced IL-6 production in human keratinocytes, confirming that the ATP-P2Y11 purinergic signaling is a common pathway of IL-6 production leading to induction of skin inflammatory diseases."

For more information on this research see: Involvement of P2Y11 receptor in silica nanoparticles 30-induced IL-6 production by human keratinocytes. Toxicology, 2014;322():61-68. Toxicology can be contacted at: Elsevier Ireland Ltd, Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland. (Elsevier - www.elsevier.com; Toxicology - www.elsevier.com/wps/product/cws_home/505518)

Our news journalists report that additional information may be obtained by contacting C. Nagakura, Tokyo University of Science, Fac Pharmaceut Sci, Dept. of Hyg Chem, Noda, Chiba 2788510, Japan. Additional authors for this research include Y. Negishi, M. Tsukimoto, S. Itou, T. Kondo, K. Takeda and S. Kojima (see also Keratinocytes).

Keywords for this news article include: Asia, Chiba, Japan, Nanoparticle, Keratinocytes, Nanotechnology, Silicon Nanocrystals, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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