Through this undertaking, JST aims to develop a new drug-discovery support system that will integrate a single-cell mass spectrometry method, developed by the RIKEN Quantitative Biology Centre's
For the development of new drugs, multiple cells are typically ground to analyse intracellular metabolism and thereby verify the efficacy and side effects of a particular candidate drug.
A drawback of this technique is that molecular changes in individual cells cannot be analysed in sufficient detail. In addition, large numbers of animal and human cells are required.
With this new system, JST aims to clarify how molecules of a candidate drug reach a specific cell and the changes that take place there.
Single-cell mass spectrometry is a technique for the analysis of target molecules that have been suctioned out from individual cells as they are being observed under a microscope.
The system that is to be developed will speed up this process by automating the identification of cells and molecules where unusual changes have taken place, and automatically capturing target molecules. In addition to speeding up analysis, this will reduce costs.
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