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Patent Issued for Thin Layer Chromatography-Surfaced Enhanced Raman Spectroscopy Chips and Methods of Use

September 3, 2014



By a News Reporter-Staff News Editor at Journal of Engineering -- According to news reporting originating from Alexandria, Virginia, by VerticalNews journalists, a patent by the inventors Zhao, Yiping (Statham, GA); Abell, Justin L. (Athens, GA); Chen, Jing (Athens, GA), filed on November 7, 2012, was published online on August 19, 2014.

The assignee for this patent, patent number 8810789, is University of Georgia Research Foundation, Inc. (Athens, GA).

Reporters obtained the following quote from the background information supplied by the inventors: "Surface enhanced Raman spectroscopy (SERS) is a highly sensitive detection platform for chemical and biological agents due to the enhancement of the Raman scattering in close vicinity (

"Thin-layer chromatography (TLC) is a well-established method used for separating components from mixtures. This method is simple and can be used to process multiple samples and standards simultaneously. In TLC the test sample is first spotted onto a thin layer of porous stationary phase (e.g., SiO.sub.2 gel) and allowed to dry. During plate development, the mobile phase (i.e., mixture of organic solvents) propagates along the TLC plate via capillary action, allowing the individual components to migrate along the solvent migration direction and spatially redistribute as a function of their varying affinity between the stationary and mobile phases. The separated components are identified by comparing the retention factors (R.sub.f, the distance travelled by a component divided by the distance travelled by the solvent) with that of standards, or by coupling with gas chromatography (GC), infrared spectroscopy (IR), nuclear magnetic resonance (NMR), or mass spectrometry (MS), but the procedures involved are time-consuming and labor-intensive."

In addition to obtaining background information on this patent, VerticalNews editors also obtained the inventors' summary information for this patent: "Embodiments of the present disclosure include thin layer chromatography (TLC) surface enhanced Raman spectroscopy chips and methods of using the chips.

"Briefly described, embodiments of the present disclosure include a method of simultaneous analyte separation and detection in a sample comprising providing a SERS-active UTLC chip, where the SERS-active UTLC chip comprises an array of nanostructures on a surface of a substrate, applying at least one sample comprising at least one analyte to the SERS-active UTLC chip, acquiring at least one SERS spectra for each sample at the sample origin on the chip, immersing at least a portion of the SERS-active UTLC chip in a mobile phase solvent, where the at least one sample is above the mobile phase solvent, developing the chip so that the at least one analyte is physically separated, acquiring at least one SERS spectra for each sample along an UTLC development direction, and analyzing all of the SERS spectra to identify the at least one analyte in each sample.

"Embodiments of the present disclosure also include a surface-enhanced Raman spectroscopic (SERS)-active ultra thin layer chromatography (UTLC) chip comprising a UTLC substrate, where the UTLC substrate comprises an array of nanostructures on a surface of a substrate.

"Embodiments of the present disclosure include a method of separating and identifying at least one component in a mixture comprising applying the mixture to a SERS-active UTLC chip, where the SERS active UTLC chip comprises an array of Ag nanorods on a surface of a substrate, where a tilt angle .beta. between an individual nanorod and the substrate surface is less than about 90 degrees, acquiring at least one SERS spectra at the origin of application, immersing the SERS-active UTLC chip into a mobile phase solvent, developing the chip so that the components in the mixture are separated and retained at different locations on the chip as a result of their different affinities to the Ag nanorods and solvent, acquiring at least one SERS spectra at intervals along the development direction, and analyzing all of the SERS spectra to identify the at least one component."

For more information, see this patent: Zhao, Yiping; Abell, Justin L.; Chen, Jing. Thin Layer Chromatography-Surfaced Enhanced Raman Spectroscopy Chips and Methods of Use. U.S. Patent Number 8810789, filed November 7, 2012, and published online on August 19, 2014. Patent URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8810789.PN.&OS=PN/8810789RS=PN/8810789

Keywords for this news article include: Nanostructural, Nanostructures, Nanotechnology, Emerging Technologies, University of Georgia Research Foundation Inc.

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Source: Journal of Engineering


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