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Studies from Inha University Provide New Data on Nitric Oxide (In Vivo Imaging of Nitric Oxide by Magnetic Resonance Imaging Techniques)

September 3, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Nitric Oxide. According to news originating from Inchon, South Korea, by NewsRx correspondents, research stated, "Nitric oxide (NO) biosensors are novel tools for real-time bioimaging of tissue oxygen changes and physiological monitoring of tissue vasculature. Nitric oxide behavior further enhances its role in mapping signal transduction at the molecular level."

Our news journalists obtained a quote from the research from Inha University, "Spectrometric electron paramagnetic resonance (EPR) and fluorometric imaging are well known techniques with the potential for in vivo bioimaging of NO. In tissues, NO is a specific target of nitrosyl compounds for chemical reaction, which provides a unique opportunity for application of newly identified NO biosensors. However, the accuracy and sensitivity of NO biosensors still need to be improved. Another potential magnetic resonance technique based on short term NO effects on proton relaxation enhancement is magnetic resonance imaging (MRI), and some NO biosensors may be used as potent imaging contrast agents for measurement of tumor size by MRI combined with fluorescent imaging. The present review provides supporting information regarding the possible use of nitrosyl compounds as NO biosensors in MRI and fluorescent bioimaging showing their measurement limitations and quantitative accuracy."

According to the news editors, the research concluded: "These new approaches open a perspective regarding bioimaging of NO and the in vivo elucidation of NO effects by magnetic resonance techniques."

For more information on this research see: In Vivo Imaging of Nitric Oxide by Magnetic Resonance Imaging Techniques. Journal of Nanomaterials, 2014;():1-13. Journal of Nanomaterials can be contacted at: Hindawi Publishing Corporation, 410 Park Avenue, 15TH Floor, #287 Pmb, New York, NY 10022, USA. (Hindawi Publishing -; Journal of Nanomaterials -

The news correspondents report that additional information may be obtained from R. Sharma, Inha University, Dept. of Biol Engn, Inchon 402751, South Korea. Additional authors for this research include J.W. Seo and S. Kwon (see also Nitric Oxide).

Keywords for this news article include: Asia, Inchon, Chemicals, Chemistry, Biosensing, South Korea, Nitric Oxide, Bioengineering, Nitrogen Oxides, Bionanotechnology, Nanobiotechnology, Reactive Nitrogen Species

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Source: Biotech Week

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