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Researchers from National Taiwan University Provide Details of New Studies and Findings in the Area of Otitis Media (Synthesis and antimicrobial...

September 5, 2014



Researchers from National Taiwan University Provide Details of New Studies and Findings in the Area of Otitis Media (Synthesis and antimicrobial activity of gold/silver-tellurium nanostructures)

By a News Reporter-Staff News Editor at Drug Week -- New research on Drugs and Therapies is the subject of a report. According to news originating from Taipei, Taiwan, by NewsRx correspondents, research stated, "Gold-tellurium nanostructures (Au-Te NSs), silver-tellurium nanostructures (Ag-Te NSs), and gold/silver-tellurium nanostructures (Au/Ag-Te NSs) have been prepared through galvanic reactions of tellurium nanotubes (Te NTs) with Au(3+), Ag(+), and both ions, respectively. Unlike the use of less environmentally friendly hydrazine, fructose as a reducing agent has been used to prepare Te NTs from TeO2 powders under alkaline conditions."

Our news journalists obtained a quote from the research from National Taiwan University, "The Au/Ag-Te NSs have highly catlaytic activity to convert nonfluorescent Amplex Red to form fluorescent product, revealing their great strength of generating reactive oxygen species (ROS). Au/Ag-Te NSs relative to the other two NSs exhibit greater antimicrobial activity toward the growth of E. coli, S. enteritidis, and S. aureus; the minimal inhibitory concentration (MIC) values of Au/Ag-Te NSs were much lower (>10-fold) than that of Ag-Te NSs and Au-Te NSs. The antibacterial activity of Au/Ag-Te NSs is mainly due to the release of Ag(+) ions and Te-related ions and also may be due to the generated ROS which destroys the bacteria membrane. In vitro cytotoxicity and hemolysis analyses have revealed their low toxicity in selected human cell lines and insignificant hemolysis in red blood cells. In addition, inhibition zone measurements using a Au/Ag-Te NSs-loaded konjac jelly film have suggested that it has great potential in practial application such as wound dressing for reducing bacterial wound infection."

According to the news editors, the research concluded: "Having great antibacterial activitiy and excellent biocompatibility, the low-cost Au/Ag-Te NSs hold great potential as effective antimicrobial drugs."

For more information on this research see: Synthesis and antimicrobial activity of gold/silver-tellurium nanostructures. Acs Applied Materials & Interfaces, 2014;6(11):8305-12. (American Chemical Society - www.acs.org; Acs Applied Materials & Interfaces - www.pubs.acs.org/journal/aamick)

The news correspondents report that additional information may be obtained from H.Y. Chang, Dept. of Chemistry, National Taiwan University , Taipei 10617, Taiwan. Additional authors for this research include J. Cang, P. Roy, H.T. Chang, Y.C. Huang and C.C Huang (see also Ear Diseases and Conditions).

Keywords for this news article include: Taipei, Taiwan, Asia, Antimicrobials, Drugs and Therapies, Emerging Technologies, Nanostructural, Nanostructures, Nanotechnology, Therapy.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Drug Week


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