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Researchers at Institute of Technology Report New Data on Blood Proteins (Deposition of superparamagnetic nanohydroxyapatite on iron-fibrin...

September 2, 2014



Researchers at Institute of Technology Report New Data on Blood Proteins (Deposition of superparamagnetic nanohydroxyapatite on iron-fibrin substrates: Preparation, characterization, cytocompatibility and bioactivity studies)

By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Proteins. According to news reporting originating in Bangalore, India, by NewsRx journalists, research stated, "In the present study, nanosized hydroxyapatite (nHAp) was formed on iron-fibrin substrates and its physico-chemical properties were characterized. The prepared iron-fibrin-nanohydroxyapatite (IF-nHAp) composite was needle shaped with an average width of about 30 nm and length of 80 nm."

The news reporters obtained a quote from the research from the Institute of Technology, "The vibrating sample magnetometer (VSM) was used to evaluate the superparamagnetic behavior of the nanocomposite, IF-nHAp. Hemolysis and ELISA (enzyme linked immunosorbent assay) were performed to evaluate the its bio/immunocompatibility and MTT (3-(4,5-dimethylazol-2-yl)-2,5-diphenyl-tetrazolium bromide) assay using osteoblast cells was performed to scrutinize its proliferative potential. Alkaline phosphatase activity (ALP) and calcium deposition were studied to investigate the osteogenic property of the nanocomposite. RT-PCR (real time-polymerase chain reaction) was used to quantify the mRNA levels of ALP, OC (osteocalcin), and OPN (osteopontin) genes involved in the osteogenic differentiation and matrix mineralization."

According to the news reporters, the research concluded: "Further, the bone bonding ability of IF-nHAp was observed by the deposition of apatite layers on the composite incubated in simulated body fluid (SBF)."

For more information on this research see: Deposition of superparamagnetic nanohydroxyapatite on iron-fibrin substrates: Preparation, characterization, cytocompatibility and bioactivity studies. Colloids and Surfaces B-Biointerfaces, 2014;120():208-214. Colloids and Surfaces B-Biointerfaces can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands (see also Proteins).

Our news correspondents report that additional information may be obtained by contacting W.S. Vedakumari, PES Inst Technol, Bangalore 560085, Karnataka, India. Additional authors for this research include V.M. Priya and T.P. Sastry.

Keywords for this news article include: Asia, India, Fibrin, Bangalore, Blood Proteins

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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