Research Conducted at Sogang University Has Updated Our Knowledge about Bone Research (Effective Immobilization of BMP-2 Mediated by Polydopamine Coating on Biodegradable Nanofibers for Enhanced in Vivo Bone Formation)
By a News Reporter-Staff News Editor at Health & Medicine Week -- Data detailed on Bone Research have been presented. According to news reporting from Seoul, South Korea, by NewsRx journalists, research stated, "Although bone morphogenic proteins (BMPs) have been widely used for bone regeneration, the ideal delivery system with optimized dose and minimized side effects is still active area of research. In this study, we developed bone morphogenetic protein-2(BMP-2) immobilized poly(L-lactide) (PLLA) nanofibers inspired by polydopamine, which could be ultimately used as membranes for guided bone regeneration, and investigated their effect on guidance of in vitro cell behavior and in vivo bone formation."
The news correspondents obtained a quote from the research from Sogang University, "Surface chemical analysis of the nanofibers confirmed successful immobilization of BMP-2 mediated by polydopamine, and about 9096 of BMP-2 was stably retained on the nanofiber surface for at least 28 days. The alkaline phosphatase activity and calcium mineralization of human mesenchymal stem cells (hMSCs) after 14 days of in vitro culture was significantly enhanced on nanofibers immobilized with BMP-2. More importantly, BMP-2 at a relatively small dose was highly active following implantation to the critical-sized defect in the cranium of mice; radiographic analysis demonstrated that 77.8 +/- 11.796 of newly formed bone was filled within the defect for a BMP-2-immobilized groups at the concentration of 124 +/- 9 ng/cm(2), as compared to 5.9 +/- 1.0 and 34.1 +/- 5.5% recovery, for a defect-only and a polydopamine-only group, respectively. Scanning and transmission electron microscopy of samples from the BMP-2 immobilized group showed fibroblasts and osteoblasts with nanofiber strands in the middle of regenerated bone tissue, revealing the importance of interaction between implanted nanofibers and the neighboring extracellular environment."
According to the news reporters, the research concluded: "Taken together, our data support that the presentation of BMP-2 on the surface of nanofibers as immobilized by utilizing polydopamine chemistry may be an effective method to direct bone growth at relatively low local concentration."
For more information on this research see: Effective Immobilization of BMP-2 Mediated by Polydopamine Coating on Biodegradable Nanofibers for Enhanced in Vivo Bone Formation. ACS Applied Materials & Interfaces, 2014;6(14):11225-11235. ACS Applied Materials & Interfaces can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Applied Materials & Interfaces - www.pubs.acs.org/journal/aamick)
Our news journalists report that additional information may be obtained by contacting H.J. Cho, Sogang Univ, Dept. of Mech Engn, Seoul 121742, South Korea. Additional authors for this research include S.K.M. Perikamana, J.H. Lee, J. Lee, K.M. Lee, C.S. Shin and H. Shin (see also Bone Research).
Keywords for this news article include: Asia, Seoul, Nanofiber, South Korea, Bone Research, Nanotechnology, Emerging Technologies
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