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Reports Summarize Immunoglobulins Study Results from University of Natural Resources and Applied Life Science (Engineering, Expression in Transgenic...

September 2, 2014



Reports Summarize Immunoglobulins Study Results from University of Natural Resources and Applied Life Science (Engineering, Expression in Transgenic Plants and Characterisation of E559, a Rabies Virus-Neutralising Monoclonal Antibody)

By a News Reporter-Staff News Editor at Life Science Weekly -- New research on Immunology is the subject of a report. According to news reporting originating from Vienna, Austria, by NewsRx correspondents, research stated, "Rabies post-exposure prophylaxis (PEP) currently comprises administration of rabies vaccine together with rabies immunoglobulin (RIG) of either equine or human origin. In the developing world, RIG preparations are expensive, often in short supply, and of variable efficacy."

Our news editors obtained a quote from the research from the University of Natural Resources and Applied Life Science, "Therefore, we are seeking to develop a monoclonal antibody cocktail to replace RIG. Here, we describe the cloning, engineering and production in plants of a candidate monoclonal antibody (E559) for inclusion in such a cocktail. The murine constant domains of E559 were replaced with human IgG1 kappa constant domains and the resulting chimeric mouse-human genes were cloned into plant expression vectors for stable nuclear transformation of Nicotiana tabacum."

According to the news editors, the research concluded: "The plant-expressed, chimeric antibody was purified and biochemically characterized, was demonstrated to neutralize rabies virus in a fluorescent antibody virus neutralization assay, and conferred protection in a hamster challenge model."

For more information on this research see: Engineering, Expression in Transgenic Plants and Characterisation of E559, a Rabies Virus-Neutralising Monoclonal Antibody. Journal of Infectious Diseases, 2014;210(2):200-208. Journal of Infectious Diseases can be contacted at: Oxford Univ Press Inc, Journals Dept, 2001 Evans Rd, Cary, NC 27513, USA. (Oxford University Press - www.oup.com/; Journal of Infectious Diseases - jid.oxfordjournals.org)

The news editors report that additional information may be obtained by contacting C.J. van Dolleweerd, Univ Nat Resources & Life Sci, Dept. of Chem, Vienna, Austria. Additional authors for this research include A.Y.H. Teh, A.C. Banyard, L. Both, H.C.T. Lotter-Stark, T. Tsekoa, B. Phahladira, W. Shumba, E. Chakauya, C.T. Sabeta, C. Gruber, A.R. Fooks, R.K. Chikwamba and J.K.C. Ma (see also Immunology).

Keywords for this news article include: Antibodies, Vienna, Europe, Austria, Immunology, Engineering, Blood Proteins, Immunoglobulins

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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