Reports from National Institute of Environmental Research Highlight Recent Findings in Myeloid Cells (Magnetite- and maghemite-induced different toxicity in murine alveolar macrophage cells)
By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Myeloid Cells have been published. According to news originating from Inchon, South Korea, by NewsRx correspondents, research stated, "The unique properties of nanoparticles and biological systems are important factors affecting the biological response following nanoparticle exposure. Iron oxide nanoparticles are classified mainly as magnetite (M-FeNPs) and maghemite (NM-FeNPs)."
Our news journalists obtained a quote from the research from the National Institute of Environmental Research, "In our previous study, NM-FeNPs induced autophagic cell death in RAW264.7, a murine peritoneal macrophage cell line, which has excellent lysosomal activity. In this study, we compared the toxicity of M-FeNPs and NM-FeNPs in MH-S, a murine alveolar macrophage cell line, which has relatively low lysosomal activity. At 24 h post-exposure, M-FeNPs decreased cell viability and ATP production, and elevated the levels of reactive oxygen species, nitric oxide, and pro-inflammatory cytokines to a higher extent than NM-FeNPs. Damage of mitochondria and the endoplasmic reticulum and the down-regulation of mitochondrial function and transcription-related genes were also higher in cells exposed to M-FeNPs than in cells exposed to NM-FeNPs (50 mu g/ml). In addition, cells exposed to M-FeNPs (50 mu g/ml) showed an increase in the number of autophagosome-like vacuoles, whereas cells exposed to NM-FeNPs formed large vacuoles in the cytosol. However, an autophagy-related molecular response was not induced by exposure to either FeNPs, unlike the results seen in our previous study with RAW264.7 cells."
According to the news editors, the research concluded: "We suggest that M-FeNPs induced higher toxicity compared to NM-FeNPs in MH-S cells, and lysosomal activity plays an important role in determining cell death pathway."
For more information on this research see: Magnetite- and maghemite-induced different toxicity in murine alveolar macrophage cells. Archives of Toxicology, 2014;88(8):1607-1618. Archives of Toxicology can be contacted at: Springer Heidelberg, Tiergartenstrasse 17, D-69121 Heidelberg, Germany. (Springer - www.springer.com; Archives of Toxicology - www.springerlink.com/content/0340-5761/)
The news correspondents report that additional information may be obtained from E.J. Park, Natl Inst Environm Res, Environm Hlth Res Department, Inchon 404708, South Korea. Additional authors for this research include H.N. Umh, D.H. Choi, M.H. Cho, W. Choi, S.W. Kim, Y. Kim and J.H. Kim (see also Myeloid Cells).
Keywords for this news article include: Asia, Inchon, Immunology, South Korea, Nanoparticle, Myeloid Cells, Nanotechnology, Alveolar Macrophages, Emerging Technologies, Connective Tissue Cells, Hemic and Immune Systems, Mononuclear Phagocyte System
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