New Sulfur Amino Acids Study Results from Fudan University Described (Yolk-Shell Upconversion Nanocomposites for LRET Sensing of Cysteine/Homocysteine)
By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Sulfur Amino Acids have been published. According to news reporting from Shanghai, People's Republic of China, by NewsRx journalists, research stated, "The fabrication of lanthanide upconversion nanocomposites as probes has become a new research hotspot due to its special advantages via utilizing upconversion luminescence (UCL) as a detection signal. Herein, a hybrid organic dye modified upconversion nanophosphor is successfully developed as a nanoprobe for cysteine/homocysteine."
The news correspondents obtained a quote from the research from Fudan University, "Yolk shell structured upconversion nanoparticles (YSUCNP) with lanthanide upconversion nanophosphor as moveable core and silica as mesoporous shell are synthesized, and a colorimetric chemodosimeter for cysteine/homocysteine is accommodated in the hollow cavities. Thus, cysteine/homocysteine can be quantitatively detected on the basis of luminescent resonance energy transfer (LRET) in a UCL turn-off pattern. The dye-loaded YSUCNP possess good dispersibility in aqueous solution; thus detection of the targeted molecule can be achieved in pure water. Cellular experiments carried out with laser-scanning upconversion luminescence microscopy further demonstrate that the dye-loaded YSUCNP can serve as an intracellular nanoprobe to detect cysteine/ homocysteine."
According to the news reporters, the research concluded: "Moreover, this dye-loading protocol can be developed as a common approach to construct other chemodosimeter-modified UCNP hybrid nanoprobes, as proved by a UCL turn-on style sensor for cyanide."
For more information on this research see: Yolk-Shell Upconversion Nanocomposites for LRET Sensing of Cysteine/Homocysteine. ACS Applied Materials & Interfaces, 2014;6(14):11190-11197. ACS Applied Materials & Interfaces can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Applied Materials & Interfaces - www.pubs.acs.org/journal/aamick)
Our news journalists report that additional information may be obtained by contacting L.Z. Zhao, Fudan University, Inst Biomed Sci, Shanghai 200433, People's Republic of China. Additional authors for this research include J.J. Peng, M. Chen, Y. Liu, L.M. Yao, W. Feng and F.Y. Li (see also Sulfur Amino Acids).
Keywords for this news article include: Asia, Shanghai, Homocysteine, Nanocomposite, Nanotechnology, Sulfur Amino Acids, Neutral Amino Acids, Sulfhydryl Compounds, Emerging Technologies, People's Republic of China
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