New Genetic Research Study Findings Recently Were Reported by Researchers at Department of Agriculture (Mapping and genotypic analysis of the NK-lysin gene in chicken)
By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on Life Science Research is now available. According to news reporting originating from Beltsville, Maryland, by NewsRx correspondents, research stated, "Antimicrobial peptides (AMP) are important elements of the first line of defence against pathogens in animals. NK-lysin is a cationic AMP that plays a critical role in innate immunity."
Our news editors obtained a quote from the research from the Department of Agriculture, "The chicken NK-lysin gene has been cloned and its antimicrobial and anticancer activity has been described but its location in the chicken genome remains unknown. Here, we mapped the NK-lysin gene and examined the distribution of a functionally significant single nucleotide polymorphism (SNP) among different chicken inbred lines and heritage breeds. A 6000 rad radiation hybrid panel (ChickRH6) was used to map the NK-lysin gene to the distal end of chromosome 22. Two additional genes, the adipocyte enhancer-binding protein 1-like gene (AEBP1) and the DNA polymerase delta subunit 2-like (POLD2) gene, are located in the same NW_003779909 contig as NK-lysin, and were thus indirectly mapped to chromosome 22 as well. Previously, we reported a functionally significant SNP at position 271 of the NK-lysin coding sequence in two different chicken breeds. Here, we examined this SNP and found that the A allele appears to be more common than the G allele in these heritage breeds and inbred lines. The chicken NK-lysin gene mapped to the distal end of chromosome 22. Two additional genes, AEBP1 and POLD2, were indirectly mapped to chromosome 22 also."
According to the news editors, the research concluded: "SNP analyses revealed that the A allele, which encodes a peptide with a higher antimicrobial activity, is more common than the G allele in our tested inbred lines and heritage breeds."
For more information on this research see: Mapping and genotypic analysis of the NK-lysin gene in chicken. Genetics Selection Evolution, 2014;46():1-7. Genetics Selection Evolution can be contacted at: Biomed Central Ltd, 236 Grays Inn Rd, Floor 6, London WC1X 8HL, England. (BioMed Central - www.biomedcentral.com/; Genetics Selection Evolution - www.gsejournal.org)
The news editors report that additional information may be obtained by contacting M.O. Lee, ARS, Dept. of Agriculture, Anim Biosci & Biotechnol Lab, Beltsville Agr Res Center, Beltsville, MD 20705, United States. Additional authors for this research include E. Yang, M. Morisson, A. Vignal, Y.Z. Huang, H.H. Cheng, W.M. Muir, S.J. Lamont, H.S. Lillehoj, S.H. Lee and J.E. Womack (see also Life Science Research).
Keywords for this news article include: Maryland, Beltsville, United States, Life Science Research, North and Central America
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