New Findings in Biological and Pharmaceutical Sciences Described from Silpakorn University (The Combination of Microneedles with Electroporation and Sonophoresis to Enhance Hydrophilic Macromolecule Skin Penetration)
By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Life Science Research have been published. According to news reporting originating from Nakorn Panom, Thailand, by NewsRx correspondents, research stated, "The objective of the present work was to investigate the effects of 3 combinatorial techniques (microneedle (MN), electroporation (EP), and sonophoresis (SN)) on the in vitro skin permeation of the hydrophilic macromolecular compound fluorescein isothiocyanate-dextran (FD-4; molecular weight (MW) 4.4 kDa). Assessment of the in vitro skin permeation of FD-4 was performed in porcine skin."
Our news editors obtained a quote from the research from Silpakorn University, "MN, EP, and SN were used as physical enhancement methods, given the potential of their various mechanisms. The total cumulative amount of FD-4 that permeated through treated skin using 2 or 3 combined methods, i.e., MN+EP, MN+SN, EP+SN, and MN+EP+SN, was investigated. Microconduits created by MN alone and in combination with the other techniques were observed under confocal laser scanning microscopy (CLSM). The histology of the treated skin was examined. In vitro skin permeation experiments revealed that the total cumulative amount of FD-4 that permeated porcine skin using 3 combined techniques (MN+EP+SN) was greater than the amount observed using a single method or 2 combinations (MN+EP, MN+SN, SN+EP). The histological images indicate no noticeable damage in the skin treated with all of the enhancement methods."
According to the news editors, the research concluded: "These results suggest that MN+EP+SN may serve as a potentially effective combination strategy to transdermally deliver various hydrophilic macromolecules without causing structural alterations or skin damage."
For more information on this research see: The Combination of Microneedles with Electroporation and Sonophoresis to Enhance Hydrophilic Macromolecule Skin Penetration. Biological & Pharmaceutical Bulletin, 2014;37(8):1373-1382. Biological & Pharmaceutical Bulletin can be contacted at: Pharmaceutical Soc Japan, 2-12-15 Shibuya, Shibuya-Ku, Tokyo, 150-0002, Japan (see also Life Science Research).
The news editors report that additional information may be obtained by contacting M. Petchsangsai, Silpakorn University, Fac Pharm, Pharmaceut Dev Green Innovat Grp PDGIG, Nakhon Pathom 73000, Thailand. Additional authors for this research include T. Rojanarata, P. Opanasopit and T. Ngawhirunpat.
Keywords for this news article include: Asia, Thailand, Nakorn Panom, Life Science Research
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