New Findings from Liaoning University Describe Advances in Blood Proteins (Studies on electrochemical oxidation of estrogenic disrupting compound bisphenol AF and its interaction with human serum albumin)
By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Proteins. According to news reporting out of Shenyang, People's Republic of China, by NewsRx editors, research stated, "Bisphenol AF (BPAF) is an environmental pollutant to disrupt endocrine system or cause cancer, thus the detection of trace BPAF is very important. In this study, a simple and highly sensitive electroanalytical method for the determination of BPAF was developed."
Our news journalists obtained a quote from the research from Liaoning University, "In pH 6.0 phosphate buffer solutions, carboxyl functionalized multi-walled carbon nanotubes (MWCNT-COOH) modified glassy carbon electrode exhibits an enhanced effectiveness for the oxidation of BPAF. This electrode exhibited two linear relationships with BPAF concentration range of 0.02 mu mol L-1 to 8.0 mu mol L-1 and a detection limit of 0.0077 mu mol L-1 (S/N =3). The proposed method was successfully applied to determine BPAF in real samples and the results were satisfactory. The MWCNT-COOH/GCE electrode showed good reproducibility, stability and anti-interference. The electrochemistry and spectroscopy methods are also described for the evaluation of BPAF-HSA interaction. In the presence of HSA, the peak currents of BPAF decreased linearly due to the formation of a super-molecular complex. The binding constant between BPAF and HSA, obtained by differential pulse voltammetry (DPV), was consistent with the fluorescence analysis."
According to the news editors, the research concluded: "The molecular modeling studies were carried out to clearly describe the interaction between BPAF and HSA."
For more information on this research see: Studies on electrochemical oxidation of estrogenic disrupting compound bisphenol AF and its interaction with human serum albumin. Journal of Hazardous Materials, 2014;276():105-111. Journal of Hazardous Materials can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Hazardous Materials - www.elsevier.com/wps/product/cws_home/502691)
Our news journalists report that additional information may be obtained by contacting X. Wang, Liaoning Univ, Coll Chem, Shenyang 110036, People's Republic of China. Additional authors for this research include J.C. Yang, Y.J. Wang, Y.H. Li, F. Wang and L. Zhang (see also Proteins).
Keywords for this news article include: Asia, Shenyang, Chemistry, Serum Albumin, Blood Proteins, Electrochemical, Acute-Phase Proteins, People's Republic of China
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