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New Findings from Golestan University in the Area of Proinsulin Described (Preparation, design for optimization and in vitro evaluation of insulin...

September 5, 2014



New Findings from Golestan University in the Area of Proinsulin Described (Preparation, design for optimization and in vitro evaluation of insulin nanoparticles integrating thiolated chitosan derivatives)

By a News Reporter-Staff News Editor at Drug Week -- Current study results on Peptide Proteins have been published. According to news reporting originating from Gorgan, Iran, by NewsRx correspondents, research stated, "This study aims at the statistical optimization and in vitro characterization of insulin nanoparticles containing thiolatd N-diethyl methyl chitosan (DEMC-Cys) and N-dimethyl ethyl chitosan (DMEC-Cys) conjugates. Insulin nanoparticles containing these conjugates were prepared by polyelectrolyte complexation (PEG) method."

Our news editors obtained a quote from the research from Golestan University, "Further optimization of nanoparticles was continued by Box-Behnken design. Morphological studies of optimized nanopaticles were performed by scanning electron microscopy (SEM). In vitro release study was carried out in phosphate buffer solution pH 6.8. Insulin nanoparticles composed of DMEC-Cys (35 % degree of quaternization and 155 mu mole thiol group/gram polymer) had more effect on minimizing particle size of insulin nanoparticles compared to DEMC-Cys (12 % degree of quaternization and 165 mu mole thiol group/gram polymer). Optimized nanoparticles were shown to have mean particle size diameter of 174 nm, zeta potential of 24.04 mV."

According to the news editors, the research concluded: "PdI of 0.196 and EE of 98.35 %. In vitro release study of the optimized nanoparticles showed 71.29 % within 240 min."

For more information on this research see: Preparation, design for optimization and in vitro evaluation of insulin nanoparticles integrating thiolated chitosan derivatives. Journal of Drug Delivery Science and Technology, 2014;24(1):40-49. Journal of Drug Delivery Science and Technology can be contacted at: Editions Sante, 47 Rue Galilee, 75116 Paris, France (see also Peptide Proteins).

The news editors report that additional information may be obtained by contacting E. Mortazavian, Golestan Univ Med Sci, Neurosci Res Center, Dept. of Pharmacol, Gorgan, Iran. Additional authors for this research include M. Amini, F.A. Dorkoosh, H. Amini, M.R. Khoshayand, T. Amini and M. Rafiee-Tehrani.

Keywords for this news article include: Iran, Asia, Gorgan, Proinsulin, Nanoparticle, Nanotechnology, Peptide Hormones, Peptide Proteins, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Drug Week


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