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New Findings from Aristotle University in the Area of Applied Materials & Interfaces Described (Lipid-like self-assembling peptide nanovesicles...

September 2, 2014



New Findings from Aristotle University in the Area of Applied Materials & Interfaces Described (Lipid-like self-assembling peptide nanovesicles for drug delivery)

By a News Reporter-Staff News Editor at Life Science Weekly -- Data detailed on Applied Materials & Interfaces have been presented. According to news reporting originating in Thessaloniki, Greece, by NewsRx journalists, research stated, "Amphiphilic self-assembling peptides are functional materials, which, depending on the amino acid sequence, the peptide length, and the physicochemical conditions, form a variety of nanostructures including nanovesicles, nanotubes, and nanovalves. We designed lipid-like peptides with an aspartic acid or lysine hydrophilic head and a hydrophobic tail composed of six alanines (i.e., ac-A6K-CONH2, KA6-CONH2, ac-A6D-COOH, and DA6-COOH)."

The news reporters obtained a quote from the research from Aristotle University, "The resulting novel peptides have a length similar to biological lipids and form nanovesicles at physiological conditions. AFM microscopy and light scattering analyses of the positively charged lipid-like ac-A6K-CONH2, KA6-CONH2 peptide formulations showed individual nanovesicles. The negatively charged ac-A6D-COOH and DA6-COOH peptides self-assembled into nanovesicles that formed clusters that upon drying were organized into necklace-like formations of nanovesicles. Encapsulation of probe molecules and release studies through the peptide bilayer suggest that peptide nanovesicles may be good candidates for sustained release of pharmaceutically active hydrophilic and hydrophobic compounds."

According to the news reporters, the research concluded: "Lipid-like peptide nanovesicles represent a paradigm shifting system that may complement liposomes for the delivery of diagnostic and therapeutic agents."

For more information on this research see: Lipid-like self-assembling peptide nanovesicles for drug delivery. Acs Applied Materials & Interfaces, 2014;6(11):8184-9. (American Chemical Society - www.acs.org; Acs Applied Materials & Interfaces - www.pubs.acs.org/journal/aamick)

Our news correspondents report that additional information may be obtained by contacting D.G. Fatouros, School of Pharmacy, Aristotle University of Thessaloniki , GR-54124 Thessaloniki, Greece. Additional authors for this research include D.A. Lamprou, A.J. Urquhart, S.N. Yannopoulos, I.S. Vizirianakis, S. Zhang and S. Koutsopoulos (see also Applied Materials & Interfaces).

Keywords for this news article include: Greece, Europe, Thessaloniki, Applied Materials & Interfaces.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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