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New Drug Delivery Study Findings Have Been Reported from C. Luo et al (Felodipine nanosuspension: a faster in vitro dissolution rate and higher oral...

September 5, 2014



New Drug Delivery Study Findings Have Been Reported from C. Luo et al (Felodipine nanosuspension: a faster in vitro dissolution rate and higher oral absorption efficiency)

By a News Reporter-Staff News Editor at Drug Week -- New research on Drugs and Therapies is the subject of a report. According to news reporting originating from Shenyang, People's Republic of China, by NewsRx correspondents, research stated, "In the present work, nanocrystals were prepared to improve oral bioavailability of felodipine. Several important formulation factors and process parameters were explored, optimized and analyzed systematically."

Our news editors obtained a quote from the research, "The prepared nanocrystals were characterized for morphology, particle size, zeta potential. possible crystallization changes, release behavior and oral absorption. The morphology of the obtained nanocrystals was found to be rod shape. The particle size and zeta potential were 140 +/- 10 nm and -29.11 mV, respectively. The X-ray diffraction (XRD) and differential scanning calorimetry (DSC) analysis indicated that felodipine had undergone crystal form transition. The dissolution rate of felodipine was significantly increased and the AUC(O-t) value of felodipine colloidal dispersion in beagle dogs was approximately 1.6-fold greater than that of the commercial tablets."

According to the news editors, the research concluded: "Nanocrystals impose a faster dissolution rate and higher oral absorption efficiency than raw crystals, and show great potential as an effective strategy for improving oral bioavailability of poorly soluble drugs."

For more information on this research see: Felodipine nanosuspension: a faster in vitro dissolution rate and higher oral absorption efficiency. Journal of Drug Delivery Science and Technology, 2014;24(2):173-177. Journal of Drug Delivery Science and Technology can be contacted at: Editions Sante, 47 Rue Galilee, 75116 Paris, France (see also Drugs and Therapies).

The news editors report that additional information may be obtained by contacting C. Luo, Northeast Pharmaceut Grp Co Ltd, Shenyang 110021, People's Republic of China. Additional authors for this research include Y. Li, J. Sun, Y. Zhang, Q. Chen, X.H. Liu and Z.G. He.

Keywords for this news article include: Asia, Shenyang, Drugs and Therapies, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Drug Week


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