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Investigators from Walailak University Release New Data on Chemical Toxicology (Neuroprotective effects of xanthone derivative of Garcinia mangostana...

September 2, 2014



Investigators from Walailak University Release New Data on Chemical Toxicology (Neuroprotective effects of xanthone derivative of Garcinia mangostana against lead-induced acetylcholinesterase dysfunction and cognitive impairment)

By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Life Science Research. According to news reporting from Nakhon Si Thammarat, Thailand, by NewsRx journalists, research stated, "Lead poisoning is a common environmental toxicity and low level of lead exposure is responsible for neurobehavioral or intelligence defects. This study was designed to investigate the protective effect of a xanthone derivative of Garcinia mangostana against lead-induced acetycholinesterase (AChE) dysfunction and cognitive impairment in mice."

The news correspondents obtained a quote from the research from Walailak University, "ICR mice were exposed to lead acetate (Pb) in drinking water (1%) with or without xanthone co-administration (100 and 200 mg/kgBW/day) for 38 days. Xanthone possesses a high phenolic content, which is positive correlation with its antioxidant activity (R-2 = 0.98). The IC50 of xanthone on scavenging free radical activities, hydroxyl radical, superoxide radical, hydrogen peroxide and nitric oxide in cell-free system were 0.48 +/- 0.08, 1.88 +/- 0.09, 2.20 +/- 0.03 and 0.98 +/- 0.40 mg/mL, respectively. We found that Pb induced AChE dysfunction and memory deficit in a dose dependent manner, indicated by in vitro and in vivo studies. However, xanthone significantly restored AChE activity in the blood and brains of mice and prevented Pb-induced neurobehavioral defect indicators with Forced Swimming and Morris water maze tests. Xanthone treatment improved all indicators compared to the Pb-treated group."

According to the news reporters, the research concluded: "Xanthone alleviates Pb-induced neurotoxicity, in part, by suppression of oxidative damage and reversing AChE activity with a reduction in learning deficit and memory loss."

For more information on this research see: Neuroprotective effects of xanthone derivative of Garcinia mangostana against lead-induced acetylcholinesterase dysfunction and cognitive impairment. Food and Chemical Toxicology, 2014;70():151-156. Food and Chemical Toxicology can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. (Elsevier - www.elsevier.com; Food and Chemical Toxicology - www.elsevier.com/wps/product/cws_home/237)

Our news journalists report that additional information may be obtained by contacting M.P. Phyu, Walailak Univ, Sch Allied Hlth Sci & Public Hlth, Nakhon Si Thammarat 80160, Thailand (see also Life Science Research).

Keywords for this news article include: Asia, Thailand, Nakhon Si Thammarat, Life Science Research

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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