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Investigators from University of Granada Release New Data on Steroid Receptors (Analytical methodology for the profiling and characterization of...

September 2, 2014



Investigators from University of Granada Release New Data on Steroid Receptors (Analytical methodology for the profiling and characterization of androgen receptor active compounds in human placenta)

By a News Reporter-Staff News Editor at Life Science Weekly -- New research on Proteins is the subject of a report. According to news originating from Granada, Spain, by NewsRx correspondents, research stated, "The exposure to endocrine disrupting chemicals during foetal development has been proposed to cause reproductive dysfunctions in the neonate or later life. In order to support such studies, an analytical method was developed to profile the receptor mediated (anti)androgenic activities present in extracts of placenta samples."

Our news journalists obtained a quote from the research from the University of Granada, "Placenta samples from women giving birth to healthy male neonates were extracted and fractionated by HPLC. Fractions containing androgen receptor (AR) activity were detected using an in vitro yeast-based human androgen receptor transcription screen. GC-MS analyses of receptor active fractions resulted in detection of chemical contaminants including antimicrobial and cosmetic compounds which exhibited AR antagonist activity in the yeast screen, and endogenously derived steroids which contributed to both the agonist and antagonistic activity in the samples."

According to the news editors, the research concluded: "The bioassay-directed fractionation methodology developed in this study revealed the potential to identify mixtures of chemical contaminants that should be investigated for potential effects on the reproductive system."

For more information on this research see: Analytical methodology for the profiling and characterization of androgen receptor active compounds in human placenta. Reproductive Toxicology, 2014;47():102-110. Reproductive Toxicology can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. (Elsevier - www.elsevier.com; Reproductive Toxicology - www.elsevier.com/wps/product/cws_home/525489)

The news correspondents report that additional information may be obtained from P. Indiveri, University of Granada, San Cecilio Hosp, Lab Med Invest, E-18071 Granada, Spain. Additional authors for this research include J. Horwood, A. Abdul-Sada, J.P. Arrebola, N. Olea and E.M. Hill (see also Proteins).

Keywords for this news article include: Spain, Europe, Granada, Steroid Receptors, Androgen Receptors, DNA-Binding Proteins, Transcription Factors

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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