News Column

Findings from M. Schmitt and Co-Researchers Provides New Data on Infection Research (Bead-based multiplex sexually transmitted infection profiling)

September 5, 2014



By a News Reporter-Staff News Editor at Health & Medicine Week -- A new study on Health and Medicine is now available. According to news reporting originating in Antwerp, Belgium, by NewsRx journalists, research stated, "Sexually transmitted infections are a significant cause of genital disease, infertility and hospital admissions. The economic impact is high."

The news reporters obtained a quote from the research, "An accurate diagnosis is often difficult and time consuming. We report the development and validation of a novel bead-based multiplex sexually transmitted infection profiling (STIP) assay that detects 18 sexually transmitted infections using a multiplex PCR followed by Luminex bead-based hybridisation. STIP was validated using urogenital samples pretested by commercially available quantitative PCR, microscopy or by culturing methods. STIP specifically detects Chlamydia trachomatis, Herpes simplex virus 1 and 2, Treponema pallidum, Trichomonas vaginalis, Neisseria gonorrhoeae, Mycoplasma (M.) genitalium, M. hominis, M. pneumonia, M. spermatophilum, Ureaplasma urealyticum and U. parvum, and quantifies bacterial vaginosis-associated Atopobium vaginae and Gardnerella vaginalis as well as three Candida species and normal genital flora-associated Lactobacillus species. STIP reached an overall concordance of 95-100% with commercially available quantitative PCR tests. Compared to Nugent score, STIP reached a sensitivity of 95% and a specificity of 86% for bacterial vaginosis detection. Candida specimens, pretested by direct culturing, were identified with a sensitivity of 97% and a specificity of 99%."

According to the news reporters, the research concluded: "STIP is a powerful high-throughput tool in assessing a broad spectrum of urogenital infections."

For more information on this research see: Bead-based multiplex sexually transmitted infection profiling. Journal of Infection, 2014;69(2):123-133. Journal of Infection can be contacted at: W B Saunders Co Ltd, 32 Jamestown Rd, London NW1 7BY, England. (Elsevier - www.elsevier.com; Journal of Infection - www.elsevier.com/wps/product/cws_home/623054)

Our news correspondents report that additional information may be obtained by contacting M. Schmitt, AML, Lab Mol & Clin Pathol RIATOL, Sonic Healthcare Benelux, B-2020 Antwerp, Belgium. Additional authors for this research include C. Depuydt, M. Stalpaert and M. Pawlita (see also Health and Medicine).

Keywords for this news article include: Europe, Antwerp, Belgium, Health and Medicine

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Health & Medicine Week


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