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Findings from E.N.J. Ford and Co-Authors Broaden Understanding of Bovine Serum Albumin [Role of Single-Walled Carbon Nanotubes on Ester Hydrolysis...

September 2, 2014



Findings from E.N.J. Ford and Co-Authors Broaden Understanding of Bovine Serum Albumin [Role of Single-Walled Carbon Nanotubes on Ester Hydrolysis and Topography of Electrospun Bovine Serum Albumin/Poly(vinyl alcohol) Membranes]

By a News Reporter-Staff News Editor at Life Science Weekly -- Fresh data on Proteins are presented in a new report. According to news reporting originating in Natick, Massachusetts, by NewsRx journalists, research stated, "Electrospun membranes were studied for the chemical deactivation of threat agents by means of enzymatic proteins. Protein loading and the surface chemistry of hybrid nanofibers influenced the efficacy by which embedded enzymes could digest the substrate of interest."

The news reporters obtained a quote from the research, "Bovine serum albumin (BSA), selected as a model protein, was electrospun into biologically active fibers of poly(vinyl alcohol), PVA. Single-walled carbon nanotubes (SWNTs) were blended within these mixtures to promote protein assembly during the process of electrospinning and subsequently the ester hydrolysis of the substrates. The SWNT incorporation was shown to influence the topography of PVA/BSA nanofibers and enzymatic activity against paraoxon, a simulant for organophosphate agents and a phosphorus analogue of p-nitrophenyl acetate (PNA). The esterase activity of BSA against PNA was uncompromised upon its inclusion within nanofibrous membranes because similar amounts of PNA were hydrolyzed by BSA in solution and the electrospun BSA. However, the availability of BSA along the fiber surface was shown to affect the ester hydrolysis of paraoxon. Atomic force microscopy images of nanofibers implicated the surface migration of BSA during the electrospinning of SWNT filled dispersions, especially as greater weight fractions of protein were added to the spinning mixtures. In turn, the PVA/SWNT/BSA nanofibers outperformed the nanotube free PVA/BSA membranes in terms of paraoxon digestion."

According to the news reporters, the research concluded: "The results support the development of electrospun polymer nanofiber platforms, modulated by SWNTs for enzyme catalytic applications relevant to soldier protective ensembles."

For more information on this research see: Role of Single-Walled Carbon Nanotubes on Ester Hydrolysis and Topography of Electrospun Bovine Serum Albumin/Poly(vinyl alcohol) Membranes. ACS Applied Materials & Interfaces, 2014;6(14):11741-11748. ACS Applied Materials & Interfaces can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Applied Materials & Interfaces - www.pubs.acs.org/journal/aamick)

Our news correspondents report that additional information may be obtained by contacting E.N.J. Ford, Natick Soldier Res Dev & Engn Center, Mol Sci & Engn Team, Natick, MA 01760, United States. Additional authors for this research include N. Suthiwangcharoen, P.A. D'Angelo and R. Nagarajan (see also Proteins).

Keywords for this news article include: Natick, Nanofiber, Fullerenes, Massachusetts, United States, Blood Proteins, Nanotechnology, Acute-Phase Proteins, Bovine Serum Albumin, Emerging Technologies, North and Central America, Single Walled Carbon Nanotubes

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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