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Findings from Aalto University Provides New Data about Molecular Engineering (Molecular engineering of avidin and hydrophobin for functional...

September 2, 2014

Findings from Aalto University Provides New Data about Molecular Engineering (Molecular engineering of avidin and hydrophobin for functional self-assembling interfaces)

By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Molecular Engineering have been published. According to news reporting originating in Espoo, Finland, by NewsRx journalists, research stated, "Control over the functionality of interfaces through biomolecular engineering is a central tool for nanoscale technology as well as many current applications of biology. In this work we designed fusion proteins that combined the surface adhesion and interfacial activity of a hydrophobin-protein together with the high affinity biotin-binding capability of an avidin-protein."

The news reporters obtained a quote from the research from Aalto University, "We found that an overall architecture that was based on a circularly permuted version of avidin, dual-chain avidin, and hydrophobin gave a highly functional combination. The protein was produced in the filamentous fungus Trichoderma reesei and was efficiently purified using an aqueous two-phase partitioning procedure. The surface adhesive properties were widely different compared to wild-type avidin. Functional characterization showed that the protein assembled on hydrophobic surfaces as a thin layer even at very low concentrations and efficiently bound a biotinylated compound."

According to the news reporters, the research concluded: "The work shows how the challenge of creating a fusion protein with proteins that form multimers can be solved by structural design and how protein self-assembly can be used to efficiently functionalize interfaces."

For more information on this research see: Molecular engineering of avidin and hydrophobin for functional self-assembling interfaces. Colloids and Surfaces B-Biointerfaces, 2014;120():102-109. Colloids and Surfaces B-Biointerfaces can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands (see also Molecular Engineering).

Our news correspondents report that additional information may be obtained by contacting K. Kurppa, Aalto Univ, Dept. of Biotechnol & Chem Technol, FI-00076 Espoo, Finland. Additional authors for this research include V.P. Hytonen, T. Nakari-Setala, M.S. Kulomaa and M.B. Linder.

Keywords for this news article include: Espoo, Europe, Finland, Nanotechnology, Emerging Technologies, Molecular Engineering

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Life Science Weekly

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