Data on Nanoparticles Reported by Researchers at National Autonomous University (Titanium dioxide nanoparticles induce strong oxidative stress and mitochondrial damage in glial cells)
By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators discuss new findings in Nanoparticles. According to news reporting originating from Mexico City, Mexico, by NewsRx correspondents, research stated, "Titanium dioxide nanoparticles (TiO2 NPs) are widely used in the chemical, electrical, and electronic industries. TiO2 NPs can enter directly into the brain through the olfactory bulb and can be deposited in the hippocampus region; therefore, we determined the toxic effect of TiO2 NPs on rat and human glial cells, C6 and U373, respectively."
Our news editors obtained a quote from the research from National Autonomous University, "We evaluated some events related to oxidative stress: (1) redox-signaling mechanisms by oxidation of 2 ',7 '-dichlorodihydrofluorescein diacetate; (2) peroxidation of lipids by cis-parinaric acid; (3) antioxidant enzyme expression by PCR in real time; and (4) mitochondrial damage by MitoTracker Green FM staining and Rh123. TiO2 NPs induced a strong oxidative stress in both glial cell lines by mediating changes in the cellular redox state and lipid peroxidation associated with a rise in the expression of glutathione peroxidase, catalase, and superoxide dismutase 2. TiO2 NPs also produced morphological changes, damage of mitochondria, and an increase in mitochondrial membrane potential, indicating toxicity."
According to the news editors, the research concluded: "TiO2 NPs had a cytotoxic effect on glial cells; however, more in vitro and in vivo studies are required to ascertain that exposure to TiO2 NPs can cause brain injury and be hazardous to health."
For more information on this research see: Titanium dioxide nanoparticles induce strong oxidative stress and mitochondrial damage in glial cells. Free Radical Biology and Medicine, 2014;73():84-94. Free Radical Biology and Medicine can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA. (Elsevier - www.elsevier.com; Free Radical Biology and Medicine - www.elsevier.com/wps/product/cws_home/525469)
The news editors report that additional information may be obtained by contacting E. Huerta-Garcia, National Autonomous University of Mexico, Fac Estudios Super Iztacala, Unidad Biomed, Mexico City 04510, DF, Mexico. Additional authors for this research include J.A. Perez-Arizti, S.G. Marquez-Ramirez, N.L. Delgado-Buenrostro, Y.I. Chirino, G.G. Iglesias and R. Lopez-Marure (see also Nanoparticles).
Keywords for this news article include: Chemicals, Chemistry, Mexico City, Light Metals, Nanotechnology, Titanium Dioxide, Emerging Technologies, North and Central America
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