News Column

Studies from University of Chicago Yield New Data on Peptides and Proteins (Gradated assembly of multiple proteins into supramolecular nanomaterials)

August 29, 2014

By a News Reporter-Staff News Editor at Science Letter -- New research on Peptides and Proteins is the subject of a report. According to news originating from Chicago, Illinois, by NewsRx correspondents, research stated, "Biomaterials exhibiting precise ratios of different bioactive protein components are critical for applications ranging from vaccines to regenerative medicine, but their design is often hindered by limited choices and cross-reactivity of protein conjugation chemistries. Here, we describe a strategy for inducing multiple different expressed proteins of choice to assemble into nanofibres and gels with exceptional compositional control."

Our news journalists obtained a quote from the research from the University of Chicago, "The strategy employs 'beta Tail' tags, which allow for good protein expression in bacteriological cultures, yet can be induced to co-assemble into nanomaterials when mixed with additional beta-sheet fibrillizing peptides. Multiple different beta Tail fusion proteins could be inserted into peptide nanofibres alone or in combination at predictable, smoothly gradated concentrations, providing a simple yet versatile route to install precise combinations of proteins into nanomaterials."

According to the news editors, the research concluded: "The technology is illustrated by achieving precisely targeted hues using mixtures of fluorescent proteins, by creating nanofibres bearing enzymatic activity, and by adjusting antigenic dominance in vaccines."

For more information on this research see: Gradated assembly of multiple proteins into supramolecular nanomaterials. Nature Materials, 2014;13(8):829-836. Nature Materials can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, England. (Nature Publishing Group -; Nature Materials -

The news correspondents report that additional information may be obtained from G.A. Hudalla, University Chicago, Comm Mol Med, Chicago, IL 60637, United States. Additional authors for this research include T. Sun, J.Z. Gasiorowski, H.F. Han, Y.F. Tian, A.S. Chong and J.H. Collier (see also Peptides and Proteins).

Keywords for this news article include: Chicago, Illinois, Amino Acids, Nanomaterial, United States, Nanotechnology, Supramolecular, Emerging Technologies, Peptides and Proteins, North and Central America

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Source: Science Letter

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