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Researchers from Institute of Science Discuss Findings in Separation Science (Separation of phenylsuccinic acid enantiomers using biphasic chiral...

August 29, 2014



Researchers from Institute of Science Discuss Findings in Separation Science (Separation of phenylsuccinic acid enantiomers using biphasic chiral recognition high-speed countercurrent chromatography)

By a News Reporter-Staff News Editor at Science Letter -- New research on Science is the subject of a report. According to news reporting from Yueyang, People's Republic of China, by NewsRx journalists, research stated, "High-speed countercurrent chromatography (HSCCC) combined with biphasic chiral recognition was successfully applied to the resolution of phenylsuccinic acid enantiomers. D-Isobutyl tartrate and hydroxypropyl-beta-cyclodextrin were employed as lipophilic and hydrophilic selectors dissolved in the organic stationary phase and aqueous mobile phase, respectively."

The news correspondents obtained a quote from the research from the Institute of Science, "The two-phase solvent system was made up of n-hexane/methyl tert-butyl ether/water (0.5:1.5:2, v/v/v). Impacts of the type and concentration of chiral selectors, the pH value of the aqueous phase solution as well as the temperature on the separation efficiency were investigated. By means of preparative HSCCC, pure enantiomer was obtained by separating 810 mg of racemate with a purity >99.5% and a recovery rate between 82 and 85%."

According to the news reporters, the research concluded: "The experimental results indicate that biphasic recognition HSCCC provide a promising means for efficient separation of racemates."

For more information on this research see: Separation of phenylsuccinic acid enantiomers using biphasic chiral recognition high-speed countercurrent chromatography. Journal of Separation Science, 2014;37(14):1736-1741. Journal of Separation Science can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany. (Wiley-Blackwell - www.wiley.com/; Journal of Separation Science - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1615-9314)

Our news journalists report that additional information may be obtained by contacting G.L. Sun, Hunan Inst Sci & Technol, Dept. of Chem & Chem Engn, Yueyang 414006, Hunan, People's Republic of China. Additional authors for this research include K.W. Tang, P.L. Zhang, W.J. Yang and G.Q. Sui (see also Science).

Keywords for this news article include: Asia, Yueyang, Science, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Science Letter


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