The assignee for this patent application is
Reporters obtained the following quote from the background information supplied by the inventors: "Implanting a chronic electrical stimulator, such as a cardiac stimulator, to deliver medical therapy(ies) is known. Examples of cardiac stimulators include implantable cardiac rhythm management (CRM) devices such as pacemakers, implantable cardiac defibrillators (ICDs), and implantable devices capable of performing pacing and defibrillating functions.
"CRM devices are implantable devices that provide electrical stimulation to selected chambers of the heart in order to treat disorders of cardiac rhythm. An implantable pacemaker, for example, is a CRM device that paces the heart with timed pacing pulses. If functioning properly, the pacemaker makes up for the heart's inability to pace itself at an appropriate rhythm in order to meet metabolic demand by enforcing a minimum heart rate. Some CRM devices synchronize pacing pulses delivered to different areas of the heart in order to coordinate the contractions. Coordinated contractions allow the heart to pump efficiently while providing sufficient cardiac output.
"It has been proposed to stimulate neural targets (referred to as neural stimulation, neurostimulation or neuromodulation) to treat a variety of pathological conditions. For example, research has indicated that electrical stimulation of the carotid sinus nerve can result in reduction of experimental hypertension, and that direct electrical stimulation to the pressoreceptive regions of the carotid sinus itself brings about reflex reduction in experimental hypertension."
In addition to obtaining background information on this patent application, VerticalNews editors also obtained the inventors' summary information for this patent application: "Various embodiments discussed herein relate to the remote sensing of paced cardiac activity.
"A system embodiment for stimulating a neural target comprises a neural stimulator, apace detector, and a controller. The neural stimulator is electrically connected to at least one electrode, and is configured to deliver a neural stimulation signal through the at least one electrode to stimulate the neural target. The pace detector is configured to use at least one electrode to sense cardiac activity and distinguish paced cardiac activity in the sensed cardiac activity from non-paced cardiac activity in the sensed cardiac activity. The controller is configured to control a programmed neural stimulation therapy using the neural stimulator and using detected paced cardiac activity as an input for the neural stimulation therapy.
"According to an embodiment of method for operating an implanted neural stimulation device, apace detector in the implanted neural stimulation device is used to sense cardiac activity and distinguish between paced cardiac activity and non-paced cardiac activity. A programmed neural stimulation therapy performed by the implanted neural stimulation device is controlled using detected cardiac activity as an input for the neural stimulation therapy.
"This Summary is an overview of some of the teachings of the present application and not intended to be an exclusive or exhaustive treatment of the present subject matter. Further details about the present subject matter are found in the detailed description and appended claims. The scope of the present invention is defined by the appended claims and their equivalents.
BRIEF DESCRIPTION OF THE DRAWINGS
"Various embodiments are illustrated by way of example in the figures of the accompanying drawings. Such embodiments are demonstrative and not intended to be exhaustive or exclusive embodiments of the present subject matter.
"FIG. 1 illustrates various technologies for sensing physiologic signals used in various embodiments of the present subject matter.
"FIG. 2 illustrates an implantable neural stimulator and an implantable CRM device, according to various embodiments.
"FIG. 3 illustrates heart sounds S1 and S2, such as may be detected using an accelerometer.
"FIG. 4 illustrates a relationship between heart sounds and both the QRS wave and left ventricular pressure.
"FIG. 5 illustrates an embodiment of a method for calculating an interval between heart sounds, used to determine heart rate.
"FIG. 6 illustrates an embodiment of a method for using heart sounds to calculate an average rate or to calculate HRV.
"FIG. 7 illustrates an embodiment of a method for using heart sounds to deter nine heart rate during time periods with neural stimulation and time periods without neural stimulation.
"FIG. 8 illustrates an embodiment of a method for using heart sounds to detect arrhythmia.
"FIG. 9 illustrates an embodiment of a method for modulating neural stimulation based on heart rate determined using heart sounds.
"FIG. 10 illustrates an embodiment of a combined neural lead with dedicated neural stimulation electrodes and cardiac electrogram sensing electrodes (unipolar to can or bipolar).
"FIG. 11 illustrates an embodiment of an implantable neural stimulation device with a neural stimulation lead and a separate sensing stub lead used to remotely detect cardiac activity.
"FIGS. 12A-12B illustrate an embodiment of a device with narrow field vector sensing capabilities.
"FIG. 13 illustrates an embodiment of a device with wide field vector sensing capabilities.
"FIG. 14 illustrates remote cardiac R-wave detection for remote cardiac rate determination, according to various embodiments.
"FIG. 15 illustrates an embodiment of a method for monitoring heart rate for feedback to a neural stimulation therapy.
"FIG. 16 illustrates an embodiment of a method for trending heart rate information for a neural stimulation therapy.
"FIG. 17 illustrates an embodiment of a method for detecting arrhythmia.
"FIG. 18 illustrates an embodiment of a method for modulating a neural stimulation therapy.
"FIG. 19 illustrates an embodiment of remote cardiac pace detection circuitry.
"FIG. 20 illustrates a flow diagram of an embodiment for detecting pulses using the pace detection circuitry illustrated in FIG. 19.
"FIG. 21 illustrates an embodiment of a method for correlating a detected pace to a right ventricle pace.
"FIG. 22 illustrates an embodiment of a method for detecting antitachycardia pacing (ATP).
"FIG. 23 illustrates an embodiment of a method that uses antitachycardia pacing as an input to a neural stimulation therapy.
"FIG. 24 illustrates various embodiments of closed loop neural stimulation that use detected pacing as art input.
"FIG. 25 illustrates an example of band-pass filtered tracheal sound, such as may be used in various embodiments.
"FIG. 26 illustrates an embodiment of a method for filtering tracheal sound.
"FIG. 27 illustrates an embodiment of a method for titrating neural stimulation.
"FIG. 28 illustrates an embodiment of a method for detecting laryngeal vibration by monitoring an accelerometer filtered to a neural stimulation frequency.
"FIG. 29 illustrates an embodiment of a method for controlling neural stimulation.
"FIG. 30 illustrates an embodiment of a method for controlling neural stimulation using a filtered accelerometer signal monitored over a neural stimulation burst.
"FIG. 31 illustrates an embodiment of a method for rapidly titrating neural stimulation therapy using accelerometer data.
"FIG. 32 illustrates an embodiment of a method for using an accelerometer to remotely sense respiratory parameter(s) for diagnostic purposes or for a closed loop neural stimulation."
For more information, see this patent application: Ternes, David J.;
Keywords for this news article include: Therapy, Angiology, Cardiology,
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