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University of Verona Details Findings in Mononuclear Phagocyte System (The inclusion into PLGA nanoparticles enables alpha-bisabolol to efficiently...

August 29, 2014



University of Verona Details Findings in Mononuclear Phagocyte System (The inclusion into PLGA nanoparticles enables alpha-bisabolol to efficiently inhibit the human dendritic cell pro-inflammatory activity)

By a News Reporter-Staff News Editor at Health & Medicine Week -- Research findings on Immunology are discussed in a new report. According to news reporting originating in Verona, Italy, by NewsRx journalists, research stated, "Alpha-bisabolol, a natural sesquiterpene alcohol, has generated considerable interest for its anti-inflammatory activity. Since the mechanisms of this anti-inflammatory action remain poorly understood, we investigated whether alpha-bisabolol affects the release of pro-inflammatory cytokines IL-12, IL-23, IL-6, and TNF alpha by human dendritic cells (DCs)."

The news reporters obtained a quote from the research from the University of Verona, "We found that alpha-bisabolol did not induce the secretion of these cytokines and did not affect their release induced upon DC challenge with lipopolysaccharide (LPS), a well-known immune cell stimulator. As alpha-bisabolol is scarcely ingested by the cells, we wondered whether the inclusion of alpha-bisabolol into nanoparticles could favor its internalization by DCs and consequently its effects on cytokine secretion. We then prepared and characterized poly(lactic-co-glycolic acid) (PLGA) nanoparticles, with a dynamic light scattering peak centered at 154 nm and a half width at half maximum of about 48 nm. These particles were unable to affect per se cytokine secretion by both resting and LPS-stimulated DCs and were internalized by human DCs as demonstrated by confocal microscopy analysis. We then loaded PLGA nanoparticles with alpha-bisabolol and we observed that PLGA-associated alpha-bisabolol did not stimulate the cytokine release by resting DCs, but decreased IL-12, IL-23, IL-6, and TNF alpha secretion by LPS-stimulated DCs."

According to the news reporters, the research concluded: "Our results indicate that alpha-bisabolol inclusion into PLGA nanoparticles represents a very promising tool for designing new anti-inflammatory, anti-pyretic and, possibly, immunosuppressive therapeutic strategies."

For more information on this research see: The inclusion into PLGA nanoparticles enables alpha-bisabolol to efficiently inhibit the human dendritic cell pro-inflammatory activity. Journal of Nanoparticle Research, 2014;16(8):1-16. Journal of Nanoparticle Research can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; Journal of Nanoparticle Research - www.springerlink.com/content/1388-0764/)

Our news correspondents report that additional information may be obtained by contacting L. Marongiu, University of Verona, Dept. of Life & Reprod Sci, Sect Biol Chem, I-37134 Verona, Italy. Additional authors for this research include M. Donini, M. Bovi, M. Perduca, F. Vivian, A. Romeo, S. Mariotto, H.L. Monaco and S. Dusi (see also Immunology).

Keywords for this news article include: Antigen-Presenting Cells, Italy, Verona, Europe, Cytokines, Immunology, Nanoparticle, Nanotechnology, Dendritic Cells, Emerging Technologies, Mononuclear Phagocyte System

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Health & Medicine Week


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