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Study Results from University of Bonn Provide New Insights into DNA Research (Switchable Reconfiguration of an Interlocked DNA Olympiadane...

August 26, 2014

Study Results from University of Bonn Provide New Insights into DNA Research (Switchable Reconfiguration of an Interlocked DNA Olympiadane Nanostructure)

By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on DNA Research have been published. According to news reporting originating in Bonn, Germany, by NewsRx journalists, research stated, "Interlocked DNA rings (catenanes) are interesting reconfigurable nanostructures. The synthesis of catenanes with more than two rings is, however, hampered, owing to low yields of these systems."

The news reporters obtained a quote from the research from the University of Bonn, "We report a new method for the synthesis of catenanes with a controlled number of rings in satisfactory yields. Our approach is exemplified by the synthesis of a five-ring DNA catenane that exists in four different configurations. By the use of nucleic acids as 'fuels' and 'antifuels', the cyclic reconfiguration of the system across four states is demonstrated. One of the states, olympiadane, corresponds to the symbol of the Olympic Games. The five-ring catenane was implemented as a mechanical scaffold for the reconfiguration of Au NPs."

According to the news reporters, the research concluded: "The advantages of DNA catenanes over supramolecular catenanes include the possibility of generating highly populated defined states and the feasibility of tethering nanoobjects to the catenanes, which act as a mechanical scaffold to reconfigure the nanoobjects."

For more information on this research see: Switchable Reconfiguration of an Interlocked DNA Olympiadane Nanostructure. Angewandte Chemie-International Edition, 2014;53(29):7499-7503. Angewandte Chemie-International Edition can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany (see also DNA Research).

Our news correspondents report that additional information may be obtained by contacting C.H. Lu, University of Bonn, Kekule Inst Organ Chem & Biochem, LIMES Program Unit Chem Biol & Med Chem, D-53121 Bonn, Germany. Additional authors for this research include X.J. Qi, A. Cecconello, S.S. Jester, M. Famulok and I. Willner.

Keywords for this news article include: Bonn, Europe, Germany, Catenanes, DNA Research, Organic Chemicals

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Source: Life Science Weekly

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