Studies from Kyoto University Add New Findings in the Area of Cancer Gene Therapy (Therapeutic applications of curcumin for patients with pancreatic cancer)
By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Research findings on Biotechnology are discussed in a new report. According to news reporting originating from Kyoto, Japan, by NewsRx editors, the research stated, "A number of preclinical studies have demonstrated anticancer effects for curcumin in various types of tumors, including pancreatic cancer. Curcumin has anticancer effects both alone and in combination with other anticancer drugs (e.g., gemcitabine, 5-fluorouracil, and oxaliplatin), and it has been shown to modulate a variety of molecular targets in preclinical models, with more than 30 molecular targets identified to date."
Our news editors obtained a quote from the research from Kyoto University, "Of these various molecules, NF-kappa B is thought to be one of the primary targets of curcumin activity. Based on these promising preclinical results, several research groups, including our own, have progressed to testing the anticancer effects of curcumin in clinical trials; however, the poor bioavailability of this agent has been the major challenge for its clinical application. Despite the ingestion of gram-level doses of curcumin, plasma curcumin levels remain at low (ng/mL) levels in patients, which is insufficient to yield the anticancer benefits of curcumin. This problem has been solved by the development of highly bioavailable forms of curcumin (THERACURMIN ®), and higher plasma curcumin levels can now be achieved without increased toxicity in patients with pancreatic cancer."
According to the news editors, the research concluded: "In this article, we review possible therapeutic applications of curcumin in patients with pancreatic cancer."
For more information on this research see: Therapeutic applications of curcumin for patients with pancreatic cancer. World Journal of Gastroenterology, 2014;20(28):9384-9391. World Journal of Gastroenterology can be contacted at: Baishideng Publishing Group Inc, 8226 Regency Dr, Pleasanton, CA 94588, USA. (Baishideng Publishing Group - www.wjgnet.com/; World Journal of Gastroenterology - www.wjgnet.com/1007-9327/current.htm)
The news editors report that additional information may be obtained by contacting M. Kanai, Kyoto University, Japan Kyoto Univ Hosp, Grad Sch Med, Dept. of Clin Oncol & Pharmacogen, Kyoto 6068507, Japan (see also Biotechnology).
Keywords for this news article include: Asia, Biotechnology, Kyoto, Japan, Oncology, Gastroenterology, Pancreatic Cancer, Pre-Trial Research, Cancer Gene Therapy, Pancreatic Neoplasms, Clinical Trials and Studies
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