Researchers at University of Sherbrooke Report New Data on DNA Research [Correlation between energy deposition and molecular damage from Auger electrons: A case study of ultra-low energy (5-18 eV) electron interactions with DNA]
By a News Reporter-Staff News Editor at Health & Medicine Week -- Data detailed on DNA Research have been presented. According to news reporting from Sherbrooke, Canada, by NewsRx journalists, research stated, "The present study introduces a new method to establish a direct correlation between biologically related physical parameters (i.e., stopping and damaging cross sections, respectively) for an Auger-electron emitting radionuclide decaying within a target molecule (e. g., DNA), so as to evaluate the efficacy of the radionuclide at the molecular level. These parameters can be applied to the dosimetry of Auger electrons and the quantification of their biological effects, which are the main criteria to assess the therapeutic efficacy of Auger-electron emitting radionuclides."
The news correspondents obtained a quote from the research from the University of Sherbrooke, "Absorbed dose and stopping cross section for the Auger electrons of 5-18 eV emitted by I-125 within DNA were determined by developing a nanodosimetric model. The molecular damages induced by these Auger electrons were investigated by measuring damaging cross section, including that for the formation of DNA single-and double-strand breaks. Nanoscale films of pure plasmid DNA were prepared via the freeze-drying technique and subsequently irradiated with low-energy electrons at various fluences. The damaging cross sections were determined by employing a molecular survival model to the measured exposure-response curves for induction of DNA strand breaks. For a single decay of I-125 within DNA, the Auger electrons of 5-18 eV deposit the energies of 12.1 and 9.1 eV within a 4.2-nm(3) volume of a hydrated or dry DNA, which results in the absorbed doses of 270 and 210 kGy, respectively. DNA bases have a major contribution to the deposited energies. Ten-electronvolt and high linear energy transfer 100-eV electrons have a similar cross section for the formation of DNA double-strand break, while 100-eV electrons are twice as efficient as 10 eV in the induction of single-strand break. Ultra-low-energy electrons (
According to the news reporters, the research concluded: "The stopping cross section is correlated with a damaging cross section (e.g., cross section for the double-strand break formation) to quantify the number of each specific lesion in a target molecule for each nuclear decay of a single Auger-electron emitting radionuclide."
For more information on this research see: Correlation between energy deposition and molecular damage from Auger electrons: A case study of ultra-low energy (5-18 eV) electron interactions with DNA. Medical Physics, 2014;41(7):412-420. Medical Physics can be contacted at: Amer Assoc Physicists Medicine Amer Inst Physics, Ste 1 No 1, 2 Huntington Quadrangle, Melville, NY 11747-4502, USA. (American Association of Physicists in Medicine - www.aapm.org; Medical Physics - online.medphys.org/)
Our news journalists report that additional information may be obtained by contacting M. Rezaee, University of Sherbrooke, Fac Med & Sci Sante, Dept. of Med Nucl & Radiobiol, Grp Sci Radiat, Sherbrooke, PQ J1H 5N4, Canada. Additional authors for this research include D.J. Hunting and L. Sanche (see also DNA Research).
Keywords for this news article include: Quebec, Canada, Sherbrooke, DNA Research, North and Central America
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