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Researchers at Institute of Experimental Biology Release New Data on Breast Cancer (The effectiveness of nano chemotherapeutic particles combined...

August 28, 2014



Researchers at Institute of Experimental Biology Release New Data on Breast Cancer (The effectiveness of nano chemotherapeutic particles combined with mifepristone depends on the PR isoform ratio in preclinical models of breast cancer)

By a News Reporter-Staff News Editor at Women's Health Weekly -- Investigators publish new report on Oncology. According to news reporting from Buenos Aires, Argentina, by NewsRx journalists, research stated, "There is clinical and experimental evidence suggesting that antiprogestins might be used for the treatment of selected breast cancer patients. Our aim was to evaluate the effect of albumin-bound paclitaxel (Nab-paclitaxel) and pegylated doxorubicin liposomes (PEG-LD) in combination with mifepristone (MFP) in experimental breast cancer models expressing different ratios of progesterone receptor (PR) isoforms A and B."

The news correspondents obtained a quote from the research from the Institute of Experimental Biology, "We used two antiprogestin-responsive (PRA >PRB) and two resistant (PRA
According to the news reporters, the research concluded: "MFP induces an increase in vessels during tissue remodeling, favoring the selective accumulation of nanoparticles inside the tumors. We propose that antiprogestins have the potential to enhance the efficacy of chemotherapy in breast tumors with a high PRA/PRB ratio."

For more information on this research see: The effectiveness of nano chemotherapeutic particles combined with mifepristone depends on the PR isoform ratio in preclinical models of breast cancer. Oncotarget, 2014;5(10):3246-60 (see also Oncology).

Our news journalists report that additional information may be obtained by contacting G. Sequeira, Institute of Experimental Biology and Medicine, IBYME-CONICET, Buenos Aires, Argentina. Additional authors for this research include S.I. Vanzulli, P. Rojas, C. Lamb, L. Colombo, M. May, A. Molinolo and C. Lanari.

Keywords for this news article include: Oncology, Argentina, Buenos Aires, Nanoparticle, South America, Breast Cancer, Nanotechnology, Women's Health, Emerging Technologies.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Women's Health Weekly


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