Recent Findings from Chemical Computing Group Provides New Insights into Immunoglobulins (Assessment of fully automated antibody homology modeling protocols in molecular operating environment)
By a News Reporter-Staff News Editor at Proteomics Weekly -- Current study results on Immunology have been published. According to news reporting originating in Montreal, Canada, by NewsRx journalists, research stated, "The success of antibody-based drugs has led to an increased demand for predictive computational tools to assist antibody engineering efforts surrounding the six hypervariable loop regions making up the antigen binding site. Accurate computational modeling of isolated protein loop regions can be quite difficult; consequently, modeling an antigen binding site that includes six loops is particularly challenging."
The news reporters obtained a quote from the research from Chemical Computing Group, "In this work, we present a method for automatic modeling of the FV region of an immunoglobulin based upon the use of a precompiled antibody x-ray structure database, which serves as a source of framework and hypervariable region structural templates that are grafted together. We applied this method (on common desktop hardware) to the Second Antibody Modeling Assessment (AMA-II) target structures as well as an experimental specialized CDR-H3 loop modeling method."
According to the news reporters, the research concluded: "The results of the computational structure predictions will be presented and discussed."
For more information on this research see: Assessment of fully automated antibody homology modeling protocols in molecular operating environment. Proteins-Structure Function and Bioinformatics, 2014;82(8):1599-1610. Proteins-Structure Function and Bioinformatics can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA (see also Immunology).
Our news correspondents report that additional information may be obtained by contacting J.K.X. Maier, Chem Comp Grp Inc, Montreal, PQ H3A 2R7, Canada.
Keywords for this news article include: Antibodies, Quebec, Canada, Montreal, Immunology, Blood Proteins, Immunoglobulins, North and Central America
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