Recent Data from
The news correspondents obtained a quote from the research, "In vitro, the masked Probody showed diminished antigen binding and cell-based activities, but when activated by appropriate proteases, it regained full activity compared to the parental anti-EGFR antibody cetuximab. In vivo, the Probody was largely inert in the systemic circulation of mice, but was activated within tumor tissue and showed antitumor efficacy that was similar to that of cetuximab. The Probody demonstrated markedly improved safety and increased half-life in nonhuman primates, enabling it to be dosed safely at much higher levels than cetuximab. In addition, we found that both Probody-responsive xenograft tumors and primary tumor samples from patients were capable of activating the Probody ex vivo."
According to the news reporters, the research concluded: "Probodies may therefore improve the safety profile of therapeutic antibodies without compromising efficacy of the parental antibody and may enable the wider use of empowered antibody formats such as antibody-drug conjugates and bispecifics."
For more information on this research see: Tumor-specific activation of an EGFR-targeting probody enhances therapeutic index. Science Translational Medicine, 2013;5(207):207ra144 (see also Membrane Proteins).
Our news journalists report that additional information may be obtained by contacting
Keywords for this news article include: Antibodies, Therapy, Protease,
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