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New Findings on Nanoparticles from Kyoto University Summarized (Mesoscopic Metal Nanoparticles Doubly Functionalized with Natural and Engineered...

August 27, 2014



New Findings on Nanoparticles from Kyoto University Summarized (Mesoscopic Metal Nanoparticles Doubly Functionalized with Natural and Engineered Lipidic Dispersants for Therapeutics)

By a News Reporter-Staff News Editor at Journal of Engineering -- Data detailed on Nanoparticles have been presented. According to news reporting originating in Kyoto, Japan, by VerticalNews journalists, research stated, "Surface engineering of mesoscopic metal nanoparticles to increase biocompatibility and cell interaction is important for improvement of their therapeutic properties. Here, we describe a strategy to stabilize mesoscopic metal nanoparticles and to enhance their cell interaction by stepwise addition of (Z)-9-octadecenoate (oleate) and a cell-penetrating peptide-fused high-density lipoprotein (cpHDL)."

The news reporters obtained a quote from the research from Kyoto University, "Oleate replaces a cytotoxic dispersant on the surface of gold nanorods (AuNRs), which enables subsequent cpHDL binding without causing aggregation. Notably, these two lipidic dispersants are probably intercalated on the surface."

According to the news reporters, the research concluded: "This procedure was also used to stabilize 20 nm spherical gold nanoparticles and 40 nm aggregates of 10 nm magnetite nanoparticles. cpHDL-bound AuNRs were internalized greater than 80 times more efficiently than poly(ethylene glycol)-conjugated AuNRs and were able to elicit cancer cell photoablation."

For more information on this research see: Mesoscopic Metal Nanoparticles Doubly Functionalized with Natural and Engineered Lipidic Dispersants for Therapeutics. ACS Nano, 2014;8(7):7370-7376. ACS Nano can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Nano - www.pubs.acs.org/journal/ancac3)

Our news correspondents report that additional information may be obtained by contacting T. Murakami, Kyoto University, Dept. of Drug Delivery Res, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan. Additional authors for this research include H. Nakatsuji, N. Morone, J.E. Heuser, F. Ishidate, M. Hashida and H. Imahori.

Keywords for this news article include: Asia, Kyoto, Japan, Engineering, Nanotechnology, Metal Nanoparticles, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Journal of Engineering


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