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New Findings in the Area of Quantum Dots Reported from K.D. Wegner and Colleagues (Three-Dimensional Solution-Phase Forster Resonance Energy Transfer...

August 29, 2014



New Findings in the Area of Quantum Dots Reported from K.D. Wegner and Colleagues (Three-Dimensional Solution-Phase Forster Resonance Energy Transfer Analysis of Nanomolar Quantum Dot Bioconjugates with Subnanometer Resolution)

By a News Reporter-Staff News Editor at Energy Weekly News -- Research findings on Quantum Dots are discussed in a new report. According to news reporting from Columbia, Maryland, by VerticalNews journalists, research stated, "Luminescent semiconductor quantum dots (QDs) play an important role in optical biosensing and, in particular, in FRET (Forster resonance energy transfer)-based luminescent probes. The QD materials that form the basis for these probes are in actuality quite heterogeneous and consist of different types of QDs with variations in material compositions, surface coatings, and available biofunctionalization strategies."

The news correspondents obtained a quote from the research, "To optimize their role in active sensors that rely on FRET, extensive physicochemical characterization is required. A technique that can provide precise information about size, shape, and bioconjugation properties of different QD-biomolecule conjugates from a single sample and measurement under actual experimental biosensing conditions would therefore be highly important for advancing QDs to a next generation nanobiosensing tool. Here, we present a detailed FRET study on a large set of QD-biomolecule conjugates, which allows for a homogeneous solution-phase size, shape, and bioconjugation analysis of peptide and protein self-assembled QDs at subnanomolar concentrations and with subnanometer resolution. Direct incorporation of luminescent Tb-complexes (Tb) in the peptides or proteins leads to Tb-to-QD FRET upon assembly to the different QD surfaces. Luminescence decay times and time-gated intensities, which precisely decode the FRET interactions, provide a wealth of useful information on the underlying composite structure and even biochemical functionality."

According to the news reporters, the research concluded: "In contrast to other high-resolution techniques, which require rather sophisticated instrumentation, well-defined experimental conditions, and low sample throughput, our technique uses a commercial time-resolved fluorescence plate reader for very fast and simple data acquisition of many aqueous samples in a standard microtiter plate."

For more information on this research see: Three-Dimensional Solution-Phase Forster Resonance Energy Transfer Analysis of Nanomolar Quantum Dot Bioconjugates with Subnanometer Resolution. Chemistry of Materials, 2014;26(14):4299-4312. Chemistry of Materials can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Chemistry of Materials - www.pubs.acs.org/journal/cmatex)

Our news journalists report that additional information may be obtained by contacting K.D. Wegner, Sotera Def Solut Inc, Columbia, MD 21046, United States. Additional authors for this research include F. Morgner, E. Oh, R. Goswami, K. Susumu, M.H. Stewart, I.L. Medintz and N. Hildebrandt.

Keywords for this news article include: Columbia, Maryland, Quantum Dots, United States, Nanotechnology, Emerging Technologies, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Energy Weekly News


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