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New Findings in Cancer Gene Therapy Described from Kanazawa University (Pathophysiological roles of Pim-3 kinase in pancreatic cancer development and...

August 25, 2014



New Findings in Cancer Gene Therapy Described from Kanazawa University (Pathophysiological roles of Pim-3 kinase in pancreatic cancer development and progression)

By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Current study results on Biotechnology have been published. According to news reporting out of Ishikawa, Japan, by NewsRx editors, research stated, "Pim-3 is a member of the provirus integration site for Moloney murine leukemia virus (Pim) family proteins that exhibit serine/threonine kinase activity. Similar to the other Pim kinases (Pim-1 and Pim-2), Pim-3 is involved in many cellular processes, including cell proliferation, survival, and protein synthesis."

Our news journalists obtained a quote from the research from Kanazawa University, "Although Pim-3 is expressed in normal vital organs, it is overexpressed particularly in tumor tissues of endoderm-derived organs, including the liver, pancreas, and colon. Silencing of Pim-3 expression can retard in vitro cell proliferation of hepatocellular, pancreatic, and colon carcinoma cell lines by promoting cell apoptosis. Pim-3 lacks the regulatory domains similarly as Pim-1 and Pim-2 lack, and therefore, Pim-3 can exhibit its kinase activity once it is expressed. Pim-3 expression is regulated at transcriptional and post-transcriptional levels by transcription factors (e.g., Ets-1) and post-translational modifiers (e.g., translationally-controlled tumor protein), respectively. Pim-3 could promote growth and angiogenesis of human pancreatic cancer cells in vivo in an orthotopic nude mouse model. Furthermore, a Pim-3 kinase inhibitor inhibited cell proliferation when human pancreatic cancer cells were injected into nude mice, without inducing any major adverse effects."

According to the news editors, the research concluded: "Thus, Pim-3 kinase may serve as a novel molecular target for developing targeting drugs against pancreatic and other types of cancer."

For more information on this research see: Pathophysiological roles of Pim-3 kinase in pancreatic cancer development and progression. World Journal of Gastroenterology, 2014;20(28):9392-9404. World Journal of Gastroenterology can be contacted at: Baishideng Publishing Group Inc, 8226 Regency Dr, Pleasanton, CA 94588, USA. (Baishideng Publishing Group - www.wjgnet.com/; World Journal of Gastroenterology - www.wjgnet.com/1007-9327/current.htm)

Our news journalists report that additional information may be obtained by contacting Y.Y. Li, Kanazawa University, Canc Res Inst, Div Mol Bioregulat, Canc Microenvironm Res Program, Kanazawa, Ishikawa 9201192, Japan (see also Biotechnology).

Keywords for this news article include: Asia, Biotechnology, Japan, Kinase, Ishikawa, Oncology, Gastroenterology, Pancreatic Cancer, Cell Proliferation, Cancer Gene Therapy, Pancreatic Neoplasms, Enzymes and Coenzymes

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Gene Therapy Week


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