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New Findings from University Medical Center Update Understanding of Nephrology (Next-generation sequencing for research and diagnostics in kidney...

August 29, 2014

New Findings from University Medical Center Update Understanding of Nephrology (Next-generation sequencing for research and diagnostics in kidney disease)

By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Health and Medicine have been published. According to news reporting from Utrecht, Netherlands, by NewsRx journalists, research stated, "The advent of next-generation sequencing technologies has enabled genetic nephrology research to move beyond single gene analysis to the simultaneous investigation of hundreds of genes and entire pathways: These new sequencing approaches have been used to identify and characterize causal factors that underlie inherited heterogeneous kidney diseases such as nephronophthisis and congenital anomalies of the kidney and urinary tract. In this Review, we describe the development of next-generation sequencing in basic and clinical research and discuss the implementation of this novel technology in routine patient management."

The news correspondents obtained a quote from the research from University Medical Center, "Widespread use of targeted and nontargeted approaches for gene identification in clinical practice will require consistent phenotyping, appropriate disease modelling and collaborative efforts to combine and integrate data analyses. Next-generation sequencing is an exceptionally promising technique that has the potential to improve the management of patients with inherited kidney diseases. However, identifying the molecular mechanisms that lead to renal developmental disorders and ciliopathies is difficult."

According to the news reporters, the research concluded: "A major challenge in the near future will be how best to integrate data obtained using next-generation sequencing with personalized medicine, including use of high-throughput disease modelling as a tool to support the clinical diagnosis of kidney diseases."

For more information on this research see: Next-generation sequencing for research and diagnostics in kidney disease. Nature Reviews Nephrology, 2014;10(8):433-444. Nature Reviews Nephrology can be contacted at: Nature Publishing Group, 75 Varick St, 9TH Flr, New York, NY 10013-1917, USA. (Nature Publishing Group -; Nature Reviews Nephrology -

Our news journalists report that additional information may be obtained by contacting K.Y. Renkema, Univ Med Center Utrecht, Dept. of Hypertens & Nephrol, NL-3508 AB Utrecht, Netherlands. Additional authors for this research include M.F. Stokman, R.H. Giles and N. Knoers (see also Health and Medicine).

Keywords for this news article include: Europe, Utrecht, Netherlands, Health and Medicine

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Health & Medicine Week

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