New Epithelial Cells Study Findings Have Been Reported by Investigators at Hasselt University (Gene expression profiles reveal distinct immunological responses of cobalt and cerium dioxide nanoparticles in two in vitro lung epithelial cell ...)
By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Epithelial Cells have been published. According to news reporting from Diepenbeek, Belgium, by NewsRx journalists, research stated, "Fragmentary knowledge exists on cellular signaling responses underlying possible adverse health effects of CoO- and CeO2-nanoparticles (NP)s after inhalation. We aimed to perform a time kinetic study of gene expression profiles induced by these NPs in alveolar A549 and bronchial BEAS-2B epithelial cells, and investigated possible immune system modulation."
The news correspondents obtained a quote from the research from Hasselt University, "The kinetics of the cell responses induced by the NPs were different between the lung epithelial models. Both CoO- and CeO2-NP exposure induced mainly downregulation of gene transcription. BEAS-2B cells were found to be more sensitive, as they showed a higher number of differentially expressed transcripts (DET) at a 10-fold lower NP-concentration than A549 cells. Hierarchical clustering of all DET indicated that the transcriptional responses were heterogeneous among the two cell types and two NPs. Between 1% and 14% DET encoding markers involved in immune processes were observed. The transcriptional impact of the metal oxide NPs appeared to be cell-dependent, both at the general and immune response level, whereas each lung epithelial cell model responded differently to the two NP types."
According to the news reporters, the research concluded: "Thus, the study provides gene expression markers and immune processes involved in CoO- and CeO2-NP-induced toxicity, and demonstrates the usefulness of comprehensive-omics studies to differentiate between NP responses."
For more information on this research see: Gene expression profiles reveal distinct immunological responses of cobalt and cerium dioxide nanoparticles in two in vitro lung epithelial cell models. Toxicology Letters, 2014;228(3):157-169. Toxicology Letters can be contacted at: Elsevier Ireland Ltd, Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland. (Elsevier - www.elsevier.com; Toxicology Letters - www.elsevier.com/wps/product/cws_home/505519)
Our news journalists report that additional information may be obtained by contacting S. Verstraelen, Hasselt Univ, Center Environm Sci, Diepenbeek, Belgium. Additional authors for this research include S. Remy, E. Casals, P. De Boever, H. Witters, A. Gatti, V. Puntes and I. Nelissen (see also Epithelial Cells).
Keywords for this news article include: Europe, Belgium, Diepenbeek, Nanoparticle, Nanotechnology, Epithelial Cells, Emerging Technologies
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC