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New Enzymes and Coenzymes Data Have Been Reported by Investigators at Ludwig Institute for Cancer Research (Common regulatory control of CTP synthase...

August 26, 2014



New Enzymes and Coenzymes Data Have Been Reported by Investigators at Ludwig Institute for Cancer Research (Common regulatory control of CTP synthase enzyme activity and filament formation)

By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Enzymes and Coenzymes have been published. According to news reporting originating from La Jolla, California, by NewsRx correspondents, research stated, "The ability of enzymes to assemble into visible supramolecular complexes is a widespread phenomenon. Such complexes have been hypothesized to play a number of roles; however, little is known about how the regulation of enzyme activity is coupled to the assembly/disassembly of these cellular structures."

Our news editors obtained a quote from the research from Ludwig Institute for Cancer Research, "CTP synthase is an ideal model system for addressing this question because its activity is regulated via multiple mechanisms and its filament-forming ability is evolutionarily conserved. Our structure-function studies of CTP synthase in Saccharomyces cerevisiae reveal that destabilization of the active tetrameric form of the enzyme increases filament formation, suggesting that the filaments comprise inactive CTP synthase dimers. Furthermore, the sites responsible for feedback inhibition and allosteric activation control filament length, implying that multiple regions of the enzyme can influence filament structure. In contrast, blocking catalysis without disrupting the regulatory sites of the enzyme does not affect filament formation or length. Together our results argue that the regulatory sites that control CTP synthase function, but not enzymatic activity per se, are critical for controlling filament assembly."

According to the news editors, the research concluded: "We predict that the ability of enzymes to form supramolecular structures in general is closely coupled to the mechanisms that regulate their activity."

For more information on this research see: Common regulatory control of CTP synthase enzyme activity and filament formation. Molecular Biology of the Cell, 2014;25(15):2282-2290. Molecular Biology of the Cell can be contacted at: Amer Soc Cell Biology, 8120 Woodmont Ave, Ste 750, Bethesda, MD 20814-2755, USA (see also Enzymes and Coenzymes).

The news editors report that additional information may be obtained by contacting C. Noree, Ludwig Inst Canc Res, Small Mol Discovery Program, La Jolla, CA 92093, United States. Additional authors for this research include E. Monfort, A.K. Shiau and J.E. Wilhelm.

Keywords for this news article include: La Jolla, Synthase, California, United States, Nanotechnology, Supramolecular, Emerging Technologies, Enzymes and Coenzymes, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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